Citation Information :
Rajanna R, Muralidhar L, AswathReddy S. To Evaluate the Role of First-trimester Glycosylated Hemoglobin as an Early Biomarker for Gestational Diabetes Mellitus. Int J Infertil Fetal Med 2024; 15 (3):153-156.
Objective: To determine the relationship between glycosylated hemoglobin (HbA1c) levels in the first-trimester of pregnancy and the development of gestational diabetes mellitus (GDM), and to analyze the maternal and fetal outcomes.
Materials and methods: It was an observational study that included 186 pregnant women in the first-trimester in whom HbA1c was measured. These women were followed up throughout pregnancy and delivery, and all untoward effects were noted.
Results: In the present study, first-trimester HbA1c greater than 5.2 was the best cutoff to predict GDM, with a sensitivity of 69.49%, specificity of 71.65%, positive predictive value (PPV) of 53.2%, and negative predictive value (NPV) of 83.5%. Among women with HbA1c >5.6%, approximately 73.5% developed GDM, 14.7% had pregnancy-induced hypertension (PIH), 2.9% had macrosomia, and 8.8% had polyhydramnios. There was a significant difference noted with respect to HbA1c; women with higher HbA1c had more maternal and fetal complications.
Conclusion: The use of HbA1c in day-to-day practice would be helpful in the prognostication of gestational diabetes, allowing for the early diagnosis of adverse outcomes. Timely intervention could thereby prevent complications.
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