International Journal of Infertility & Fetal Medicine

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VOLUME 15 , ISSUE 2 ( May-August, 2024 ) > List of Articles

RETROSPECTIVE COHORT STUDY

Platelet-rich Plasma in Managing a Thin Endometrium: An Interventional Study

Nitin L Lad, Neha N Lad, Radhika A Limaye

Keywords : Adjuvant therapy, Assisted reproductive technology outcome, Endometrial thickness, Platelet rich plasma, Recurrent implantation failure, Thin endometrium

Citation Information : Lad NL, Lad NN, Limaye RA. Platelet-rich Plasma in Managing a Thin Endometrium: An Interventional Study. Int J Infertil Fetal Med 2024; 15 (2):115-119.

DOI: 10.5005/jp-journals-10016-1342

License: CC BY-NC 4.0

Published Online: 28-10-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Aims and background: Endometrial thickness <7 mm is frequently associated with recurrent implantation failure and poor reproductive outcomes along with obstetric and perinatal complications, leading to paramount emotional and financial stress on the patients. Novel strategies are being implemented to mitigate a thin endometrium, one of which is the administration of autologous platelet-rich plasma (PRP). In this study, we have examined the efficacy of PRP in increasing the endometrial thickness. Materials and methods: Our retrospective cohort study included 37 patients, of whom 15 received conventional hormone replacement therapy (HRT) and 22 patients received an additional intrauterine infusion of autologous PRP. Outcomes in the form of endometrial thickness and pregnancy rates were assessed. Endometrial thickness of <7 mm was used as a cutoff value for cycle cancellation. Results: A significant increase in endometrial thickness was noted upon PRP administration (7.773 vs 6.367 mm, p = 0.001). PRP-treated group resulted in a lower cycle cancellation rate since 73% of the patients achieved a thickness of >7 mm, whereas none of the patients achieved this thickness when treated with conventional HRT. The pregnancy rates were comparable between the two groups. Conclusion: Owing to its autologous nature, noninvasive and safe use, autologous PRP can be considered a promising adjuvant for managing a thin endometrium. Clinical significance: A thin endometrium is a challenging situation for both patients and clinicians alike. Given the positive impact of PRP, our study will help clinicians to explore its use, especially where the conventional HRT treatments remain insufficient.


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