International Journal of Infertility & Fetal Medicine

Register      Login

VOLUME 14 , ISSUE 2 ( May-August, 2023 ) > List of Articles

CASE REPORT

Recurrent Neurodevelopmental Disorders in Subsequent Pregnancies in a Couple with Third-degree Consanguineous Marriage: Case Report

PV Aishwarya, Sahana Sreenivas, SK Manjula

Keywords : Case report, Consanguineous, Neurodevelopmental, Pregnancies

Citation Information : Aishwarya P, Sreenivas S, Manjula S. Recurrent Neurodevelopmental Disorders in Subsequent Pregnancies in a Couple with Third-degree Consanguineous Marriage: Case Report. Int J Infertil Fetal Med 2023; 14 (2):105-107.

DOI: 10.5005/jp-journals-10016-1312

License: CC BY-NC 4.0

Published Online: 12-05-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Abstract

Introduction: There is a poor understanding of the molecular mechanisms of neurodevelopmental and metabolic morbidity affecting the fetus in pregnancy. Case description: The case has two living children, born of a third-degree consanguineous marriage, both affected by neurodevelopmental disorders. Studies have shown maternal inflammation in pregnancy was attributed to increased neurodevelopmental disorders in the baby. Subclinical inflammation in our patient was seen by histopathology of the placenta showing maternal inflammatory response stage-I grade-I. Other multifactorial causes should be evaluated preconceptionally. Subclinical inflammation in our patient, as seen by histopathology of the placenta, shows maternal inflammatory response stage-I grade-I. Conclusion: Follow-up of the baby prompt antepartum surveillance, along with postnatal metabolic screening for neurodevelopmental diseases, needs to be stressed to detect any central nervous system (CNS) abnormalities in the present pregnancy.


PDF Share
  1. Edlow AG, Vora NL, Hui L, et al. Maternal obesity affects fetal neurodevelopmental and metabolic gene expression: a pilot study. PloS One 2014;9(2):e88661. DOI: 10.1371/journal.pone.0088661
  2. Sagrillo-Fagundes L, Assunção Salustiano EM, Yen PW, et al. Melatonin in pregnancy: effects on brain development and CNS programming disorders. Curr Pharm Des 2016;22(8):978–986. DOI: 10.2174/1381612822666151214104624
  3. Mighell AS, Johnstone ED, Levene M, et al. Postnatal investigations: management and prognosis for fetuses with CNS anomalies identified in utero excluding neurosurgical problems. Prenat Diagn 2009;29(4):442–449. DOI: 10.1002/pd.2245
  4. Han VX, Patel S, Jones HF, et al. Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review. Transl Psychiatry 2021;11(1):1–2. DOI: 10.1038/s41398-021-01198-w
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.