International Journal of Infertility & Fetal Medicine

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VOLUME 13 , ISSUE 1 ( January-April, 2022 ) > List of Articles

Original Article

Impact of Two Doses of Agonist Trigger on Assisted Reproductive Technology Outcome

Radha Vembu, Sanjeeva R Nellepalli, Monna Pandurangi, Siddhartha Nagireddy

Keywords : Agonist trigger, ART outcome, Oocyte maturation, Serum LH

Citation Information : Vembu R, Nellepalli SR, Pandurangi M, Nagireddy S. Impact of Two Doses of Agonist Trigger on Assisted Reproductive Technology Outcome. Int J Infertil Fetal Med 2022; 13 (1):1-4.

DOI: 10.5005/jp-journals-10016-1255

License: CC BY-NC 4.0

Published Online: 19-01-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Abstract

Background: Serum luteinizing hormone (LH) levels are measured on trigger day and 12 hours post-gonadotropin releasing hormone (GnRH) agonist trigger for final oocyte maturation. The impact of 12-hour serum LH on the prediction of suboptimal response and outcome of assisted reproductive technology (ART) is controversial. Aim: To evaluate the impact of two doses of agonist trigger 12 hours apart irrespective of 12-hour serum LH levels on ART outcome. Settings and design: Retrospective cohort study at a tertiary care university hospital. Subjects and methods: Eighty-six infertile women with predicted hyper-response, administered agonist trigger 12 hours apart, and have undergone Intracytoplasmic Sperm Injection (ICSI) with frozen embryo transfer (FET) over 3 years were included. They were grouped based on 12-hour serum LH into <15 IU/L, 15–30 IU/L, and >30 IU/L. The baseline characteristics and ART outcome were compared among the three groups. Statistical analysis: SPSS 23.0 version, Chi-square test, One-way ANOVA with post hoc test. Results: The study groups were comparable with regard to baseline characteristics, oocytes retrieved, mature oocytes metaphase II (MII) (p = 0.421), day three grade-I embryos and embryos available for freezing (p = 0.419). The cumulative pregnancy rate (p = 0.753), miscarriage rate (p = 0.421) and ongoing pregnancy/cumulative live birth rate (CLBR) per retrieval (p = 0.892) were comparable. Conclusion: Administration of two doses of agonist trigger 12 hours apart is an effective solution in low-resource settings to avoid suboptimal response without compromising the ART outcome. Clinical significance: Administration of two doses of agonist trigger is an effective way to avoid suboptimal response in low-resource setting and can avoid LH estimation 12 hours post-trigger.


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