Citation Information :
Pandiyan R, Jayachandran KD, Natarajan P. First Postembryo Transfer Beta-hCG Level and Pregnancy Outcome in an Assisted Reproductive Technology Program. Int J Infertil Fetal Med 2012; 3 (2):57-62.
To evaluate the prognostic value of first postembryo transfer beta human chorionic gonadotropin (hCG) levels in pregnancy outcome in an assisted reproductive technology (ART) program.
Subjects
Seventy-one women with an initial beta-hCG value of greater than 5 mIU/ml postembryo transfer in the ART program were taken in to the study. The beta-hCG test was done 14 days after embryo transfer. The period of study was from January 2008 to August 2010.
Observations
A significant correlation was found in beta-hCG values between viable and nonviable pregnancies. In women who had a day 2 embryo transfer the mean beta-hCG value was 608 ± 580 mIU/ml, in comparison to women who had a day 5 transfer 1,527 ± 2,024 mIU/ml, and this was statistically significant.
Women who had a single embryo transfer had a mean betahCG level of 168 mIU/ml, two embryos 464 mIU/ml and three embryos 612 mIU /ml.
Mean beta-hCG value was highest in women who developed gestational diabetes [2,074 mIU/ml] women with pregnancyinduced hypertension (PIH) had a mean beta-hCG value of 674 mIU/ml, and with antepartum hemorrhage the value was lower 220 mIU/ml.
Conclusion
To summarize, beta-hCG level is an useful marker for prognosticating early pregnancy well being, for predicting multiple pregnancies. When interpreting the first beta-hCG level uniformly after 2 weeks of embryo transfer, day of transfer of embryos should be taken into account. The number of embryos transferred does not alter the beta-hCG level significantly. BetahCG level implications in pregnancy complications, like gestational diabetes (GDM), PIH, APH, require further research and would be a useful tool for early screening and surveillance of pregnancy.
How to cite this article
Jayachandran KD, Natarajan P, Pandiyan R. First Postembryo Transfer Beta-hCG Level and Pregnancy Outcome in an Assisted Reproductive Technology Program. Int J Infertility Fetal Med 2012;3(2): 57-62.
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