International Journal of Infertility & Fetal Medicine

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VOLUME 8 , ISSUE 3 ( September-December, 2017 ) > List of Articles

CASE REPORT

First Case of Successful Implantation and Live Birth after Double Trophectoderm Biopsy before and after Vitrification on the Same Cohort of Blastocyst

Harsha K Bhadarka, Nayana H Patel, Kruti B Patel, Yuvraj D Jadeja, Molina N Patel, Niket Hitesh Patel

Citation Information : Bhadarka HK, Patel NH, Patel KB, Jadeja YD, Patel MN, Patel NH. First Case of Successful Implantation and Live Birth after Double Trophectoderm Biopsy before and after Vitrification on the Same Cohort of Blastocyst. Int J Infertil Fetal Med 2017; 8 (3):120-124.

DOI: 10.5005/jp-journals-10016-1160

License: CC BY-NC 4.0

Published Online: 01-01-2014

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Introduction

To report the first case of live birth after double trophectoderm biopsy before and after vitrification on the same cohort of blastocyst in our knowledge.

Design

Case report.

Patient

A 36-year-old female with a history of 13 years of active married life for treatment of infertility.

Main outcome measure

Live birth after double trophectoderm biopsy.

Results

Double biopsy pre- and postvitrification and its positive outcome.

Conclusion

Preimplantation genetic screening and diagnosis (PGS/PGD), though an invasive procedure on the embryos, when done meticulously would not dampen the implantation potential of the embryo and second biopsy could be a feasible option to salvage embryos with inconclusive or suspected false-positive PGS/PGD reports.

How to cite this article

Bhadarka H, Patel NH, Jadeja YD, Patel KB, Patel NH, Patel MN. First Case of Successful Implantation and Live Birth after Double Trophectoderm Biopsy before and after Vitrification on the Same Cohort of Blastocyst. Int J Infertil Fetal Med 2017;8(3):120-124.


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  1. The impact of biopsy on human embryo developmental potential during preimplantation genetic diagnosis. BioMed Res Int 2016;2016:1-10.
  2. Human embryonic development after blastomere removal: A time-lapse analysis. Hum Reprod 2012 Jan;27(1):97-105.
  3. Pregnancies and live births after trophectoderm biopsy and preimplantation genetic testing of human blastocysts. Fertil Steril 2005 Dec;84(6):1628-1636.
  4. Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates. Fertil Steril 2007 Mar;87(3):496-503.
  5. Moving to blastocyst biopsy for preimplantation genetic diagnosis and single embryo transfer at Sydney IVF. Fertil Steril 2004 Aug;82(2):295-298.
  6. Birth of a healthy infant following trophectoderm biopsy from blastocysts for PGD of β-thalassaemia major: Case report. Hum Reprod 2005 Jul;20(7):1855-1859.
  7. Correlation between standard blastocyst morphology, euploidy and implantation: an observational study in two centers involving 956 screened blastocysts. Hum Reprod 2014 Jun;29(6):1173-1181.
  8. The blastocyst. Hum Reprod 2012;27(S1):i72-i91.
  9. Outcomes of blastocysts biopsied and vitrified once versus those cryopreserved twice for euploid blastocyst transfer. Reprod Biomed Online 2014 Jul;29(1):59-64.
  10. Pregnancy after rebiopsy and vitrification of blastocysts following allele dropout after day 3 biopsy. Fertil Steril 2011 Mar;95(3):1122.e1-1122.e2.
  11. Successful implantation and live birth of a healthy boy after triple biopsy and double vitrification of oocyte-embryo-blastocyst. SpringerPlus 2015 Jan;4:22.
  12. Diagnostic efficiency, embryonic development and clinical outcome after the biopsy of one or two blastomeres for preimplantation genetic diagnosis. Hum Reprod 2008 Mar;23(3):481-492.
  13. Preimplantation genetic screening (PGS) still in search of a clinical application: a systematic review. Reprod Biol Endocrinol 2014;12:22.
  14. Is the hypothesis of preimplantation genetic screening (PGS) still supportable? A review. J Ovarian Res 2017;10:21.
  15. Detecting mosaicism in trophectoderm biopsies: current challenges and future possibilities. Hum Reprod 2017 Mar;32(3):492-498.
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