International Journal of Infertility & Fetal Medicine

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VOLUME 8 , ISSUE 1 ( January-April, 2017 ) > List of Articles

RESEARCH ARTICLE

Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers

Pratap Kumar, Muralidhar V Pai, Sapna V Amin, DS Preethi, Lavanya Rai, M Jayaraman Nambiar

Citation Information : Kumar P, Pai MV, Amin SV, Preethi D, Rai L, Nambiar MJ. Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers. Int J Infertil Fetal Med 2017; 8 (1):18-23.

DOI: 10.5005/jp-journals-10016-1142

License: CC BY-NC 4.0

Published Online: 01-04-2017

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Introduction

The aim of this study was to evaluate the relevance of routinely done laboratory parameters in women with hypertensive disorders in pregnancy.

Materials and methods

Hypertensive pregnant women were divided into two groups based on perinatal outcome as those with and without poor perinatal outcome. They were analyzed with various laboratory tests done at the time of diagnosis: Hematological parameters, such as hemoglobin, hematocrit, platelet count, total leukocyte count, and differential count; renal parameters, such as serum urea, creatinine, and uric acid; liver function tests; and serum lactate dehydrogenase (LDH). Coagulation parameters, such as prothrombin time, activated partial thromboplastin time, and international normalized ratio were compared between the two groups. Data were presented as mean ± standard deviation; á level of p < 0.05 was set as statistically significant.

Results

Among the various hematological parameters, platelet count showed statistically significant differences between hypertensives with and without perinatal mortality or morbidity (p = 0.029, p = 0.029 respectively). All renal parameters showed statistically significant differences (p ≤ 0.005). Serum aspartate aminotransferase (p = 0.034) among the liver parameters and serum LDH (p = 0.024) showed statistically significant differences between the two groups. Coagulation parameters were abnormal among patients with thrombocytopenia.

Conclusion

Blood pressure alone is not sufficient in monitoring women with hypertensive disorders in pregnancy. Laboratory parameters that are cost-effective and routinely done in most laboratories are significant in assessing the severity of maternal disease and the perinatal outcome. It can hence, be used to monitor hypertensive women in pregnancy.

How to cite this article

Preethi DS, Rai L, Nambiar MJ, Kumar P, Pai MV, Amin SV. Role of Laboratory Investigations to Assess Maternal and Perinatal Outcome in Hypertensive Mothers. Int J Infertil Fetal Med 2017;8(1):18-23.


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  1. Relevance of measurement of hematological parameters in subjects with pregnancy induced hypertension. Nitte Univ J Health Sci 2014 Mar;4(1):15-20.
  2. Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study. BJOG 2012 Mar;119(4):484-492.
  3. Biochemical and hematological investigations in pregnancy induced hypertension. J Cell Tissue Res 2012 Jan;12(1):3009-3013.
  4. Maternal and foetal outcomes in pregnancy induced hypertension – a hospital based study. Int J Pharm Sci Invent 2014 Apr;3(4):23-26.
  5. Predictive value of plasma haematocrit level in early diagnosis of pre-eclampsia. East Mediterr Health J 2011 Oct;17(10):744-748.
  6. Hypertention. In: Gabbe SG, Niebyl JR, Galan HL, Jauniaux ER, Landon MB, Simpson JL, Driscoll DA, editors. Obstetrics: normal and problem pregnancies. 6th ed. Vol. 35. Elsevier Saunders; 2012. p. 779-825.
  7. Evaluation of platelet counts and platelet indices and their significant role in pre-eclampsia and eclampsia. J Evol Med Dent Sci 2014;3(12): 3216-3219.
  8. Evaluation of platelet indices and platelet counts and their significance in preeclampsia and eclampsia. Int J Biol Med Res 2011 Jan;2(1):425-428.
  9. Placental disease and the maternal syndrome of preeclampsia: missing links? Curr Hypertens Rep 2013 Dec;15(6):590-599.
  10. Evaluation of maternal systemic inflammatory response in preeclampsia. Taiwan J Obstet Gynecol 2015 Apr;54(2):160-166.
  11. Serum uric acid and homocysteine as predictors of pre-eclampsia. J Diabetes Metab 2013;4:259.
  12. Prognostic significance of serum uric acid in women with gestational hypertension. Hypertension 2011 Oct;58(4):704-708.
  13. First trimester uric acid and adverse pregnancy outcomes. Am J Hypertens 2011 Apr;24(4):489-495.
  14. Evaluation of RFTs, LFTs and ascorbic acid in pre-eclampsia among women of Indore. Ind J Fund Appl Life Sci 2011;1(4):312-315.
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