PCOS, Prevalence, Oligomenorrhea, Weight gain, Acne, LH, Prolactin
Citation Information :
Mangalath AA, Alias A, Sajith M, Nimbargi V, Kumdale S. Sociodemographic Characteristics and Clinical Presentation of Infertile Women with Polycystic Ovary Syndrome in a Tertiary Care Hospital. Int J Infertil Fetal Med 2018; 9 (1):14-18.
Background: Infertility has been an issue of concern especially for women for decades, and one of the identified etiological factors is polycystic ovary syndrome (PCOS) that impact on ovulation and conception.
Aim: This study aims to study the sociodemographic characteristics and clinical presentationof infertile women with (POS).
Materials and methods : In this prospective case-control study, out of 150 infertile patients 75 women served as PCOS group. The demographic details such as age, socioeconomic class, employment status residential area, Body mass index, menstrual patterns, clinical presentation, and infertility related lab values were noted.The collected data were statistically analyzed using the Chi-square test.
Results: The prevalence of PCOS was high in the age group 24 to 27 years (37.33%), from middle socioeconomic class (45%), residing in urban areas (62.67%) and housewives (65.33%). Most of the PCOS patients were overweight (32%) and obese (21.33%) and showed statistical significance p = 0.021 and p = 0.021 respectively. Oligomenorrhea (54.67%) and amenorrhea (40%) were the commonly found clinical presentations. Weight gain (p = 0.000) and acne (p = 0.049) were found to be significant. Also, a significant relationship was seen for Luteinizing Hormone (LH) (p = 0.003) and Prolactin (p = 0.001) in both groups.
Conclusion: In this study, the prevalence of PCOS was high in patients from a middle socio-economic class, residing in urban areas and obese patients. Oligomenorrhea was found to be the most common clinical presentation in PCOS patients. Furthermore, evidence of high LH and Prolactin levels were found that is known to be associated with hyperandrogenism in PCOS patients.
Teede H, Deeks A, Moran L. Polycystic ovary syndrome: A complex conditions with psychological, reproductive and metabolic manifestations that impact on health across the lifespan. BMC Medicine. 2010;8(41).
Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. The Journal of Clinical Endocrinology & Metabolism. 2004 Jun 1;89(6):2745- 2749.
Mandrelle K, Kamath MS, Bondu DJ, Chandy A, Aleyamma TK, George K. Prevalence of metabolic syndrome in women with polycystic ovary syndrome attending an infertility clinic in a tertiary care hospital in south India. Journal of human reproductive sciences. 2012 Jan;5(1):26-33.
Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS. Clinical characteristics of polycystic ovary syndrome in Indian women. Indian J Endocrinol Metab. 2013;17(1):138-145.
Rodin DA, Bano G, Bland JM, Taylor K, Nussey SS. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clinical endocrinology. 1998 Jul 1;49(1):91-99.
Roe AH, Dokras A. The Diagnosis of Polycystic Ovary Syndrome in Adolescents. Reviews in Obstetrics and Gynecology. 2011;4(2):45-51.
Lakshmi KS, Jayasutha J, Chandrasekar A. A Study on Prevalence of Polycystic Ovary Syndrome at a Tertiary Care Hospital. Age. 2015 Jan 1;25:6.
Omokanye LO, Ibiwoye-Jaiyeola OA, Olatinwo AW, Abdul IF, Durowade KA, Biliaminu SA. Polycystic ovarian syndrome: Analysis of management outcomes among infertile women at a public health institution in nigeria. The Nigerian Journal of General Practice. 2015 Jul 1;13(2):44.
Gill H, Tiwari P, Dabadghao P. Prevalence of polycystic ovary syndrome in young women from North India: A Communitybased study. Indian journal of endocrinology and metabolism. 2012 Dec;16(Suppl 2):S389.
Dhagat V, Shah P, Thakar R, Deliwala K. Study of 100 cases of infertility in polycystic ovarian syndrome and its management outcome. International Journal of Medical Science and Public Health. 2013 Oct 1;2(4):1041-1046.
Surekha T, Himabindu Y, Sriharibabu M. Impact of socioeconomic status on ovarian reserve markers. J Hum Reprod Sci. 2016;6(3):201-204.
Merkin SS, Azziz R, Seeman T, Calderon-Margalit R, Daviglus M, Kiefe C, et al. Socioeconomic status and polycystic ovary syndrome. Journal Of Women's Health. 2011 Mar 1;20(3):413-419.
Dasgupta S, Reddy BM. The Role of Epistasis in the Etiology of Polycystic Ovary Syndrome among Indian Women: SNP SNP and SNP Environment Interactions. Annals of human genetics. 2013 Jul;77(4):288-298.
Sarkar S, Das M, Mukhopadhyay B, Chakrabarti CS, Majumder PP. High prevalence of metabolic syndrome and its correlates in two tribal populations of India and the impact of urbanization. Indian J Med Res. 2006;123(5):679-686.
Saxena P, Prakash A, Nigam A, Mishra A. Polycystic ovary syndrome: Is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index. Indian J EndocrinolMetab, 2012;16(6):996-999.
Balen AH, Conway GS Kaltas G, Techatraisak K, Manning PJ, West C, et al. Polycystic ovarian syndrome: The spectrum of disorder in 1741 patients. Hum Reprod. 1995; (8):2107-2111.
B Hussein, Shahla A. Prevalence and characteristics ofthe polycystic ovarian syndrome in a sample of infertile Kurdish women attending IVF infertilitycentere in maternity teaching hospital of Erbil City. Open J Obstet Gynecol. 2013;3;577-585.
GulabKanwar D, Jain DN, Shekawat DM, Sharma DN. Estimation of LH, FSH, Prolactin and TSH Levels In Polycystic Ovarian Syndrome and Correlation of LH and FSH with Serum TSH Levels. IOSR Journal of Dental and Medical Sciences. 2015;14(5):64-68.
Janssen OE, Mehlmauer N, Hahn S, Offner AH, Gartner R. High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. European journal of endocrinology. 2004 Mar 1;150(3):363-369.
Bracero N, Zacur HA. Polycystic ovary syndrome and hyperprolactinemia. Obstetrics and gynecology clinics of North America. 2001 Mar 1;28(1):77-84.
Carmina E, Rosato F, Maggiore M, Gagliano AM, Indovina D, Janni A. Prolactin secretion in polycystic ovary syndrome (PCO): correlation with the steroid pattern. European Journal of Endocrinology. 1984 Jan 1;105(1):99-104.