International Journal of Infertility & Fetal Medicine

Register      Login

VOLUME 8 , ISSUE 2 ( May-August, 2017 ) > List of Articles

ORIGINAL ARTICLE

Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Ahmed T Alahmar

Citation Information : Alahmar AT. Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia. Int J Infertil Fetal Med 2017; 8 (2):45-49.

DOI: 10.5005/jp-journals-10016-1147

License: CC BY-NC 4.0

Published Online: 01-08-2017

Copyright Statement:  Copyright © 2017; The Author(s).


Abstract

Introduction

Accumulating evidence suggests that oxidative stress plays an important role in the development of male infertility and recently antioxidants have been tried to treat men with idiopathic infertility.

Objective

To assess the effect of treatment with vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 on seminal fluid parameters in infertile men with idiopathic oligoasthenozoospermia.

Materials and methods

A prospective randomized trial was conducted on 32 infertile men with idiopathic oligoasthenozoospmia who received a daily supplement of one caplet containing vitamin C (90 mg/day), vitamin E (15 mg/day), coenzyme Q10 (4 mg/day), selenium (30 µg/day), and zinc (5 mg/day) for 3 months. Semen analysis was performed at baseline and 3 months after treatment using World Health Organization (WHO) 2010 guidelines.

Results

Significant improvement in sperm concentration was observed after combination therapy (9.13 ± 4.29 vs 11.3 ± 6.05 × 106/mL, p < 0.05). Sperm progressive motility (18.1 ± 8.68 vs 24.6 ± 10.2%, p < 0.01) and total motility (28.4 ± 8.71 vs 34.4 ± 11.7%, p < 0.01) also increased significantly following treatment. No change, however, was observed in semen volume or the proportion of sperms with normal morphology.

Conclusion

The combination of vitamin C, vitamin E, zinc, selenium, and coenzyme Q10 can significantly improve sperm concentration and motility in infertile men with idiopathic oligo­asthenozoospermia, which could be attributed to their synergistic antioxidant action.

How to cite this article

Alahmar AT. Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia. Int J Infertil Fetal Med 2017;8(2):45-49.


HTML PDF Share
  1. Is there a place for nutritional supplements in the treatment of idiopathic male infertility? Arch Ital Urol Androl 2014 Sep;86(3):164-170.
  2. Review of clinical trials on effects of oral antioxidants on basic semen and other parameters in idiopathic oligoasthenoteratozoospermia. BioMed Res Int 2014 Mar;2014:426951.
  3. Selenium-vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate. Int J Gen Med 2011 Jan;4:99-104.
  4. Male infertility testing: reactive oxygen species and antioxidant capacity. Fertil Steril 2014 Dec;102(6):1518-1527.
  5. Antioxidant supplements and semen parameters: an evidence based review. Int J Reprod Biomed (Yazd) 2016 Dec;14(12):729-736.
  6. Diagnostic application of total antioxidant capacity in seminal plasma to assess oxidative stress in male factor infertility. J Assist Reprod Genet 2016 May;33(5):627-635.
  7. Male infertility: the effect of natural antioxidants and phytocompounds on seminal oxidative stress. Diseases 2017 Mar;5(9):1-26.
  8. CoQ10 and L-Carnitine attenuate the effect of high LDL and oxidized LDL on spermatogenesis in male rats. Drug Res (Stuttg) 2013 Dec;64(10):510-515.
  9. Semen quality in relation to antioxidant intake in a healthy male population. Fertil Steril 2013 Dec;100(6):1572-1579.
  10. Study of the effects of oral zinc supplementation on peroxynitrite levels, arginase activity and NO synthase activity in seminal plasma of Iraqi asthenospermic patients. Reprod Biol Endocrinol 2014 Jan;12:1.
  11. Effect of coenzyme Q10 supplementation on antioxidant enzymes activity and oxidative stress of seminal plasma: a double-blind randomised clinical trial. Andrologia 2014 Mar;46(2):177-183.
  12. Coenzyme Q10 treatment in infertile men with idiopathic asthenozoospermia: a placebo-controlled, double-blind randomized trial. Fertil Steril 2009 May;91(5):1785-1792.
  13. Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA. Andrologia 2013 Jun;45(3):211-216.
  14. Prospective open-label study on the efficacy and tolerability of a combination of nutritional supplements in primary infertile patients with idiopathic astenoteratozoospermia. Arch Ital Urol Androl 2012 Sep;84(3):137-140.
  15. Combination clomiphene citrate and antioxidant therapy for idiopathic male infertility: a randomized controlled trial. Fertil Steril 2010 May;93(7):2232-2235.
  16. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: WHO Press; 2010.
  17. Effects of the reduced form of coenzyme Q10 (Ubiquinol) on semen parameters in men with idiopathic infertility: a double-blind, placebo controlled, randomized study. J Urol 2012 Aug;188(2):526-531.
  18. Comparison of the effect of a combination of eight micronutrients versus a standard mono preparation on sperm parameters. Reprod Biol Endocrinol 2016 Dec;14(1):84.
  19. Effect of astaxanthin, vitamin E, and vitamin C in combination with calorie restriction on sperm quality and quantity in male rats. J Diet (Suppl) 2017 May;14(3):252-263.
  20. Combination of vitamin E and clomiphene citrate in treating patients with idiopathic oligoasthenozoospermia: a prospective, randomized trial. Andrology 2015 Sep;3(5):864-867.
  21. Impact of seminal trace element and glutathione levels on semen quality of Tunisian infertile men. BMC Urol 2012 Dec;12(1):6.
  22. Coenzyme Q10 improves seminal oxidative defense but does not affect on semen parameters in idiopathic oligoasthenoteratozoospermia: a randomized double-blind, placebo controlled trial. J Endocrinol Invest 2011 Sep;34(8):e224-e228.
  23. Effect of vitamin C on male fertility in rats subjected to forced swimming stress. J Clin Diagn Res 2014 Jul;8(7):HC05-HC08.
  24. Oral zinc supplementation restore high molecular weight seminal zinc binding protein to normal value in Iraqi infertile men. BMC Urol 2012 Dec;12(1):32.
  25. Blood serum and seminal plasma selenium, total antioxidant capacity and coenzyme Q10 levels in relation to semen parameters in men with idiopathic infertility. Biol Trace Elem Res 2014 Jun;159(1-3):46-51.
  26. The association between dietary antioxidant intake and semen quality in infertile men. Med J Islam Repub Iran 2013 Nov;27(4):204-209.
  27. The effect of coenzyme Q10 supplementation on partner pregnancy rate in infertile men with idiopathic oligoasthenoteratozoospermia: an open-label prospective study. Int Urol Nephrol 2012 Jun;44(3):689-700.
  28. Differences in blood and semen oxidative status in fertile and infertile men, and their relationship with sperm quality. Reprod Biomed Online 2012 Sep;25(3):300-306.
  29. Zinc therapy improves adverse effects of long term administration of copper on epididymal sperm quality of rats. Iran J Reprod Med 2013 Jul;11(7):577-582.
  30. Role of selenium in male reproduction – a review. Anim Reprod Sci 2014 Apr;146(1-2):55-62.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.