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VOLUME 7 , ISSUE 2 ( May-August, 2016 ) > List of Articles


Implication of ABO Blood Type on Ovarian Reserve in Indian Women

C Chandana, C Shankarappa

Citation Information : Chandana C, Shankarappa C. Implication of ABO Blood Type on Ovarian Reserve in Indian Women. Int J Infertil Fetal Med 2016; 7 (2):49-51.

DOI: 10.5005/jp-journals-10016-1127

License: CC BY-NC 4.0

Published Online: 01-12-2012

Copyright Statement:  Copyright © 2016; The Author(s).



To explore the association between ABO blood type and ovarian reserve, as reflected by early follicular phase follicle stimulating hormone (FSH) levels.

Materials and methods

In this cross-sectional observational study, early follicular phase (day 3) serum levels of FSH (IU/L) and information on blood types (O, A, B, AB), patient age, and body mass index (BMI) were collected from 300 female patients, who were undergoing fertility evaluation at Vydehi Institute of Medical Sciences and Research Centre (VIMS & RC), Bengaluru. Serum FSH > 10 IU/L was taken as a measure of decreased ovarian reserve (DOR). Data distribution for FSH, age, BMI were analyzed and nonparametric tests were used for comparison across blood groups. Pearson's correlation test was used to determine the relationship between elevated FSH and blood types after adjusting for age and BMI.


Proportions of blood types O, A, B, and AB were 42, 24.3, 28.7, and 5% respectively. Mean age (years) and BMI (kg/m2) among study group were 34.08 ± 3.48 and 24.34 ± 2.56 respectively. Out of 300 women, 240 women had serum FSH < 10 IU/L and 60 women had serum FSH > 10 IU/L. Women with blood type “O” (32 out of 60) were twice as likely to exhibit FSH > 10 IU/L (p = 0.02) compared to “A” and “B” blood type.


Our results have shown that there is an association between ABO blood type and DOR among Indian women. Blood group “O” appears to be associated with DOR that is independent of advancing age and BMI.

How to cite this article

Chandana C, Shankarappa C. Implication of ABO Blood Type on Ovarian Reserve in Indian Women. Int J Infertil Fetal Med 2016;7(2):49-51.

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  1. Prognostic assessment of female fecundity. Lancet 1987 Sep 19;2(8560):645-647.
  2. Follicle-stimulating hormone levels on cycle day 3 are predictive of in vitro fertilization outcome. Fertil Steril 1989 Apr;51(4):651-654.
  3. Basal follicle-stimulating hormone level is a better predictor of in vitro fertilization performance than age. Fertil Steril 1991 Apr;55(4):784-791.
  4. A systematic review of tests predicting ovarian reserve and IVF outcome. Hum Reprod Update 2006 Nov-Dec;12(6):685-718.
  5. Declining ovarian reserve adversely influences granulosa cell viability. Fertil Steril 2009 Jun;91(6):2611-2615.
  6. Elevated basal FSH and embryo quality: lessons from extended culture embryos: raised FSH and blastocyst quality. J Assist Reprod Genet 2009 Jun;26(6):313-318.
  7. Reproductive aging is associated with altered gene expression in human luteinized granulosa cells. Reprod Sci 2010 Jan;17(1):56-67.
  8. Implications of blood type for ovarian reserve. Hum Reprod 2011 Sep;26(9):2513-2517.
  9. Association of blood group A with early-onset ovarian hyperstimulation syndrome. Transfus Clin Biol 2008 Dec;15(6):395-401.
  10. The role of maternal age in assisted reproduction. Hum Reprod 1995 Oct;10 (Suppl 1):165-173.
  11. Life table analysis of pregnancy rates in a general infertility population relative to ovarian reserve and patient age. Hum Reprod 1995 Jul;10(7):1706-1710.
  12. The detection of diminished ovarian reserve in infertile women. Am J Obstet Gynecol 1998 Sep;179(3 Pt 1):804-812.
  13. Reproductive outcome in patients with diminished ovarian reserve. Fertil Steril 2001 Oct;76(4):666-669.
  14. Molecular genetic basis of the histo-blood group ABO system. Nature 1990 May 17;345(6272):229-233.
  15. Natural and recombinant A and B gene encoded glycosyltransferases. Transfus Med 2001 Aug;11(4):315-323.
  16. Expression of the histo-blood group ABO gene defined glycosyltransferases in epithelial tissues. J Oral Pathol Med 1990 Jul;19(6):251-256.
  17. Oocyte-specific deletion of complex and hybrid N-glycans leads to defects in preovulatory follicle and cumulus mass development. Reproduction 2009 Feb;137(2):321-331.
  18. Mutations in NR5A1 associated with ovarian insufficiency. N Engl J Med 2009 Mar 19;360(12): 1200-1210.
  19. Blood group and ovarian hyperstimulation syndrome. Fertil Steril 2010 Jan;93(1):270-271.
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