International Journal of Infertility & Fetal Medicine

Register      Login

VOLUME 6 , ISSUE 3 ( September-December, 2015 ) > List of Articles

RESEARCH ARTICLE

Clinical Outcomes of Tamoxifen and Clomiphene Citrate in Intrauterine Insemination Cycles

Asifa Majeed, PS Divyashree

Citation Information : Majeed A, Divyashree P. Clinical Outcomes of Tamoxifen and Clomiphene Citrate in Intrauterine Insemination Cycles. Int J Infertil Fetal Med 2015; 6 (3):118-121.

DOI: 10.5005/jp-journals-10016-1113

License: CC BY-NC 4.0

Published Online: 01-08-2012

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Background

Both selective estrogen receptor modulators, tamoxifen and clomiphene have been used for ovulation induction for patients with anovulatory infertility. The aim of this study is to compare the effectiveness of tamoxifen to clomiphene on clinical outcome in intrauterine insemination (IUI) cycles.

Materials and methods

It is a retrospective clinical study. Two hundred and seven women undergoing IUI cycles from July 2013 to July 2014 at Milann—The fertility centre, Bengaluru, India were analyzed. Tamoxifen was administered in the dose of 40 mg starting from day 2/3 of the menstrual cycle for a period of 5 days and clomiphene citrate (CC) was administered in the dose of 100 mg from day 2/3 of menstrual cycle for 5 days. Monitoring of ovulation was done by transvaginal ultrasound from day 5/6 till dominant follicle size was more than 18 mm. Highly purified human chorionic gonadotrophin (hCG) in the dose of 5000 IU was given. Double insemination was done at 24 and 36 hours. Luteal phase support was given in form of dydrogesterone 10 mg twice a day for 14 days. Serum beta-hCG was done after 14 days.

Result

In our study, 76 patients recieved clomiphene citrate (37%) and 126 patients received tamoxifen (62.9%). Both the groups were comparable in terms of age, period of infertility, FSH, LH, antral follicle count and their human menopausal gonadotropin (hMG) requirement (Table 1). Thirteen patients (23.6%) in CC group and 42 patients (76.4%) in tamoxifen group had positive serum beta hCG result. p-value was found to be significant (p = 0.016) (Table 2).

Conclusion

Tamoxifen was associated with better endometrial thickness and pregnancy rate when compared to clomiphene citrate in ovarian stimulation in IUI cycles.

How to cite this article

Majeed A, Divyashree PS, Rao KA. Clinical Outcomes of Tamoxifen and Clomiphene Citrate in Intrauterine Insemination Cycles. Int J Infertil Fetal Med 2015;6(3):118-121.


PDF Share
  1. Infertility therapy. Effect of innovations and increasing experience. J Reprod Med 1980 Jul;25(1):41-46.
  2. Induction of ovulation with MRL/41: Preliminary report. JAMA 1961 Oct 14;178:101-104.
  3. Ovulation and pregnancy rates with clomiphene citrate. Obstet Gynecol 1978 Mar;51(3):265-269.
  4. A decade's experience with an individualized clomiphene treatment regimen including its effect on the postcoital test. Fertil Steril 1982 Feb;37(2):161-167.
  5. The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. Fertil Steril 1989 Feb;73(2):187-190.
  6. The induction of ovulation by tamoxifen. J Obstet Gynaecol Br Cmnwlth 1973 Sep;80(9):844-847.
  7. The effect of three anti-oestrogen drugs on cervical mucus quality and in-vitro sperm-cervical mucus interaction in ovulatory women. Hum Reprod 1993 Mar;8(3):437-441.
  8. Effect of two antiestrogens, clomiphene citrate and tamoxifen, on cervical mucus and sperm-cervical mucus interaction. Int J Fertil Women's Med 1997 May-Jun;42(3):215-218.
  9. A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction. Fertil Steril 2001 May;75(5):1024-1026.
  10. A practical approach to clomiphene therapy. Clin Obstet Gynecol 1984 Dec;27(4):953-965.
  11. Action of tamoxifen on folliculogenesis in the menstrual cycle of infertile patients. Fertil Steril 1983 Aug;40(2):210-214.
  12. Tamoxifen treatment in women with failure of clomiphene citrate therapy. Austr NZ J Obstet Gynaecol 1989 May;29(2):173-175.
  13. Comparison of tamoxifen and clomiphene citrate for ovulation induction: a metaanalysis. Hum Reprod 2005 June;20(6):1511-1515.
  14. Comparison between tamoxifen and clomiphene therapy in women with anovulation. Arch Gynecol 1979;227(4):279-288.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.