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VOLUME 6 , ISSUE 1 ( January-April, 2015 ) > List of Articles


Assessment of Uterine Receptivity by the Subendometrial-Endometrial Blood Flow Distribution Pattern in Frozenthawed Embryo Transfer Cycles

Divya Sardana

Citation Information : Sardana D. Assessment of Uterine Receptivity by the Subendometrial-Endometrial Blood Flow Distribution Pattern in Frozenthawed Embryo Transfer Cycles. Int J Infertil Fetal Med 2015; 6 (1):35-39.

DOI: 10.5005/jp-journals-10016-1099

License: CC BY-NC 4.0

Published Online: 01-04-2012

Copyright Statement:  Copyright © 2015; The Author(s).



To investigate the correlation of blood flow detected by 2-Dimensional Power Doppler (2D-PD) sonography in the subendometrial-endometrial unit with the pregnancy outcome in frozen-thawed embryo transfer (FET) cycles.

Study design

Prospective non-randomized observational study.

Materials and methods

A total of 127 patients undergoing their first FET cycle were recruited and prepared using hormone replacement therapy. All patients were evaluated for subendometrial-endometrial blood flow by 2D-PD once the endometrium was ≥7 mm thick. Progesterone supplement was added and transfer of 2 to 3 cleavage stage good quality embryos was done after 3 days.


The difference in the BMI, FSH, LH and endometrial thickness of women in the three zones was not statistically significant (p > 0.05). However, women with blood flow in zone 1 were of older age as compared to women in zone 3 with a statistically significant difference (p = 0.0001). In the present study, the overall pregnancy rate was 35.43% (45/127). Women having blood flow in zone 3 or 4 showed a rising trend of pregnancy rate as compared to those in zone 1 and 2 although it was not statistically significant (p = 0.15). But, clinical pregnancy and implantation rates were significantly higher in women with zone 3 or 4 penetration compared with zone 1 or 2 penetration (p = 0.03 and 0.01, respectively).


The subendometrial-endometrial vascularity has a useful predictive value for pregnancy outcome in FET cycles. However, larger studies are needed to reach definite conclusion.

How to cite this article

Sardana D. Assessment of Uterine Receptivity by the Subendometrial-Endometrial Blood Flow Distribution Pattern in Frozen-Thawed Embryo Transfer Cycles. Int J Infertil Fetal Med 2015;6(1):35-39.

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