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VOLUME 6 , ISSUE 1 ( January-April, 2015 ) > List of Articles

RESEARCH ARTICLE

Assessment of Uterine Receptivity by the Subendometrial-Endometrial Blood Flow Distribution Pattern in Frozenthawed Embryo Transfer Cycles

Divya Sardana

Citation Information : Sardana D. Assessment of Uterine Receptivity by the Subendometrial-Endometrial Blood Flow Distribution Pattern in Frozenthawed Embryo Transfer Cycles. Int J Infertil Fetal Med 2015; 6 (1):35-39.

DOI: 10.5005/jp-journals-10016-1099

License: CC BY-NC 4.0

Published Online: 01-04-2012

Copyright Statement:  Copyright © 2015; The Author(s).


Abstract

Objective

To investigate the correlation of blood flow detected by 2-Dimensional Power Doppler (2D-PD) sonography in the subendometrial-endometrial unit with the pregnancy outcome in frozen-thawed embryo transfer (FET) cycles.

Study design

Prospective non-randomized observational study.

Materials and methods

A total of 127 patients undergoing their first FET cycle were recruited and prepared using hormone replacement therapy. All patients were evaluated for subendometrial-endometrial blood flow by 2D-PD once the endometrium was ≥7 mm thick. Progesterone supplement was added and transfer of 2 to 3 cleavage stage good quality embryos was done after 3 days.

Results

The difference in the BMI, FSH, LH and endometrial thickness of women in the three zones was not statistically significant (p > 0.05). However, women with blood flow in zone 1 were of older age as compared to women in zone 3 with a statistically significant difference (p = 0.0001). In the present study, the overall pregnancy rate was 35.43% (45/127). Women having blood flow in zone 3 or 4 showed a rising trend of pregnancy rate as compared to those in zone 1 and 2 although it was not statistically significant (p = 0.15). But, clinical pregnancy and implantation rates were significantly higher in women with zone 3 or 4 penetration compared with zone 1 or 2 penetration (p = 0.03 and 0.01, respectively).

Conclusion

The subendometrial-endometrial vascularity has a useful predictive value for pregnancy outcome in FET cycles. However, larger studies are needed to reach definite conclusion.

How to cite this article

Sardana D. Assessment of Uterine Receptivity by the Subendometrial-Endometrial Blood Flow Distribution Pattern in Frozen-Thawed Embryo Transfer Cycles. Int J Infertil Fetal Med 2015;6(1):35-39.


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  1. The role of ultrasonography in the evaluation of endometrial receptivity following assisted reproductive treatments: a critical review. Hum Reprod Update 1996;2(4):323-335.
  2. Ultrasound markers of implantation. Ultrasound Rev Obstet Gynecol 2002;2:110-123.
  3. Are endometrial parameters by three-dimensional ultrasound and power Doppler angiography related to in vitro fertilization/embryo transfer outcome? Fertil Steril 2008;89(1):111-117.
  4. Assessment of uterine receptivity by the endometrial-subendometrial blood flow distribution pattern in women undergoing in vitro fertilization-embryo transfer. Fertil Steril 2002;78(2):245-251.
  5. Endometrial thickness, morphology, vascular penetration and velocimetry in predicting implantation in an in vitro fertilization program. Ultrasound Obstet Gynecol 1995;6(3):191-198.
  6. Endometrial vascularity and ongoing pregnancy after IVF. Eur J Obstet Gynecol Reprod Biol 2002;104(2):137-143.
  7. Blood flow changes in uterine and ovarian vasculature and predictive value of transvaginal pulsed colour Doppler ultrasonography in an in vitro fertilization programme. Hum Reprod 1995;10(3): 688-693.
  8. Uterine vascularity during stimulation and its correlation with implantation and in vitro fertilization. Hum Reprod 1995;10(6):1497-1501.
  9. Uterine and ovarian perfusion during the periovulatory period assessed by transvaginal color Doppler. Fertil Steril 1993;60(3):439-443.
  10. The uterine biophysical profile. Ultrasound Obstet Gynecol 1995;5(1):67-68.
  11. Structure and function of endometrial blood vessels. Hum Reprod Update 1996;2(1):57-62.
  12. The relationship of color and power doppler ultrasound parameters of pulsatility and resistance indices and sub-endometrial blood flow with endometrial thickness on day prior to progesterone administration and their relationship to clinical pregnancy rate following frozen embryo transfer. Fertil Steril 2003;80(3):S123.
  13. The impact of embryonic development and endometrial maturity on the timing of implantation. Fertil Steril 1992;58(3):537-542.
  14. Use of immunocytochemistry of progesterone and estrogen receptors for endometrial dating. J Clin Endocrinol Metab 1988;67(1):80-87.
  15. Immunocytochemical study of progesterone receptors in the human endometrium during the menstrual cycle. Lab Invest 1988;59(6):862-869.
  16. Role of estradiol in the rise in follicle-stimulating hormone levels during the luteal-follicular transition. J Clin Endocrinol Metab 1993;77(2):439-442.
  17. An insight into early reproductive processes through the in vivo model of ovum donation. J Clin Endocrinol Metab 1991;72(2):408-414.
  18. Preparation of the human endometrium for implantation. Ann NY Acad Sci 1991;622:212-219.
  19. Hormonal manipulation of endometrial maturation. J Clin Endocrinol Metab 1989;68(4):801-807.
  20. Unexplained infertility and the role of uterine receptivity. Clinics North America 1997;8:523-543.
  21. Ovarian stimulation protocol for in vitro fertilization with gonadotropin-releasing hormone agonist widens the implantation window. Fertil Steril 1990;53(5):859-866.
  22. Assessing uterine receptivity in 2001: ultrasonographic glances at the new millennium. Ann NY Acad Sci 2001;943:185-202.
  23. In vitro fertilization: the degree of endometrial insufficiency varies with the type of ovarian stimulation. Fertil Steril 1988;50(3):457-462.
  24. The window of embryo transfer and efficiency of human conception in vivo. Fertil Sertil 1991;55(1):114-118.
  25. Preliminary report of an ultrasonography and colour Doppler uterine score to predict uterine receptivity in an in vitro fertilization programme. Hum Reprod 1998;13(6): 1669-1673.
  26. The relationships between endometrial thickness, and blood flow and pregnancy rates in in vitro fertilization. Hum Reprod 1999;14(4):1067-1071.
  27. Different implantation rates after transfers of cryopreserved embryos originating from donated oocytes or from regular in vitro fertilization. Fertil Steril 1990; 54(4):682-688.
  28. Role of endometrial blood flow assessment with color Doppler energy in predicting pregnancy outcome of IVF-ET cycles. Reprod Biol Endocrinol 2010;18(8):122.
  29. A uterine ultrasonographic scoring system as a method for the prognosis of embryo implantation in an ICSI program. Fertil Steril 2001;76(3):S189.
  30. Assessment of endometrial-subendometrial blood flow detected by color doppler sonography and uterine receptivity in infertile women. Acta Medica Iranica 2008;46(6):461-466.
  31. Assessment of endometrial and ovarian characteristics using three dimensional power Doppler ultrasound to predict response in frozen embryo transfer cycles. Reprod Biol Endocrinol 2009;25(7):151.
  32. The role of endometrial and subendometrial vascularity measured by three-dimensional power Doppler ultrasound in the prediction of pregnancy during frozen–thawed embryo transfer cycles. Hum Reprod 2006;21(6):1612-1617.
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