Preterm premature rupture of membranes (PPROM) complicates approximately 3% of all births, but accounts for 30% of neonatal morbidity and mortality among premature gestations. Prediction of latency period for women with PPROM is imprecise and therefore consulting women with PPROM about their predicted latency period is a difficult task. The studies are limited, thus more information is required to support clinical decisions and to provide prognostic information in cases of expectant management following PPROM.

We conducted a prospective observational study of women with singleton pregnancies presenting with rupture of membranes. A total of 120 women presenting with PPROM from 26 to 36 weeks with rupture of membrane were included in this study.

Advanced maternal age >30 years was found to be associated with prolongation of latency period (p = 0.000). Nulliparity was found to be associated with shortening of latency period (p = 0.012). An inverse association between gestational age at the time of presentation and latency period was established. The average gain in duration of latency period by not doing a digital examination was found to be statistically significant (p = 0.000). Gestational age and duration of latency period were found to be the important predictors of neonatal outcome.

In the current study, several predictive factors were identified which affect the duration of the latency period in cases of PPROM. This information may assist clinician in risk stratification and in providing consultation regarding the natural course of expectant management for women presenting with PPROM.

Singhal S, Puri M, Gami N. An Analysis of Factors Affecting the Duration of Latency Period and Its Impact on Neonatal Outcome in Patients with PPROM. Int J Infertility Fetal Med 2012;3(3):87-91.