International Journal of Infertility & Fetal Medicine

Register      Login

VOLUME 3 , ISSUE 2 ( May-August, 2012 ) > List of Articles

RESEARCH ARTICLE

First Postembryo Transfer Beta-hCG Level and Pregnancy Outcome in an Assisted Reproductive Technology Program

Radha Pandiyan, Krithika Devi Jayachandran, Pandiyan Natarajan

Citation Information : Pandiyan R, Jayachandran KD, Natarajan P. First Postembryo Transfer Beta-hCG Level and Pregnancy Outcome in an Assisted Reproductive Technology Program. Int J Infertil Fetal Med 2012; 3 (2):57-62.

DOI: 10.5005/jp-journals-10016-1042

License: CC BY-NC 4.0

Published Online: 01-08-2012

Copyright Statement:  Copyright © 2012; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To evaluate the prognostic value of first postembryo transfer beta human chorionic gonadotropin (hCG) levels in pregnancy outcome in an assisted reproductive technology (ART) program.

Subjects

Seventy-one women with an initial beta-hCG value of greater than 5 mIU/ml postembryo transfer in the ART program were taken in to the study. The beta-hCG test was done 14 days after embryo transfer. The period of study was from January 2008 to August 2010.

Observations

A significant correlation was found in beta-hCG values between viable and nonviable pregnancies. In women who had a day 2 embryo transfer the mean beta-hCG value was 608 ± 580 mIU/ml, in comparison to women who had a day 5 transfer 1,527 ± 2,024 mIU/ml, and this was statistically significant.

Women who had a single embryo transfer had a mean betahCG level of 168 mIU/ml, two embryos 464 mIU/ml and three embryos 612 mIU /ml.

Mean beta-hCG value was highest in women who developed gestational diabetes [2,074 mIU/ml] women with pregnancyinduced hypertension (PIH) had a mean beta-hCG value of 674 mIU/ml, and with antepartum hemorrhage the value was lower 220 mIU/ml.

Conclusion

To summarize, beta-hCG level is an useful marker for prognosticating early pregnancy well being, for predicting multiple pregnancies. When interpreting the first beta-hCG level uniformly after 2 weeks of embryo transfer, day of transfer of embryos should be taken into account. The number of embryos transferred does not alter the beta-hCG level significantly. BetahCG level implications in pregnancy complications, like gestational diabetes (GDM), PIH, APH, require further research and would be a useful tool for early screening and surveillance of pregnancy.

How to cite this article

Jayachandran KD, Natarajan P, Pandiyan R. First Postembryo Transfer Beta-hCG Level and Pregnancy Outcome in an Assisted Reproductive Technology Program. Int J Infertility Fetal Med 2012;3(2): 57-62.


PDF Share
  1. Predictive value of hCG level 14 days after embryo transfer. J Assist Reprod Gen 1995;12(1):13-14.
  2. Human chorionic gonadotropin as a predictor of outcome in assisted reproductive technology pregnancies. Fertil Steril 2000;73: 270-74.
  3. Serum human chorionic gonadotropin measurements may predict pregnancy outcome and multiple gestation after in vitro fertilization. Fertility and Sterility 2002;78(3):540-42.
  4. The relationship between HCG and relaxin in normal pregnancies vs preimplantation spontaneous abortions. Clin Endocrinol 1993;60:871-75.
  5. Serum hCG 12 days after embryo transfer in predicting pregnancy outcome. Hum Reprod 2002;17(7):1901-05.
  6. Clincal laboratory medicine: Clinical application of laboratory data. Chapter 32 Tests in Obstetrics 543.
  7. The micro-elisa total Beta-hCG test. http://www.leinco.com/ELISA/human-chorionicgonadotropin.
  8. Early beta-hCG levels predict IVF pregnancy viability. Ob/Gyn News, June 1, 2005.
  9. Limitations of qualitative serum beta-hCG assays in the diagnosis of ectopic pregnancy. J Reprod Med 1983 Dec;28(12):838-42.
  10. Normal and abnormal implantation in spontaneous in vivo and in vitro human pregnancies. J Reprod Fertil 1991;92:556-65.
  11. Recurrent pregnancy loss textbook (2nd ed). Jaypee Brothers 2007;56.
  12. Maternal serum hCG is higher in the presence of a female fetus as early as week 3 post-fertilization. Human Reproduction 2005;17(2):485-89.
  13. Relationship between the sex of the foetus and the amount of human chorionic gonadotropin in placentae from the 10th to the 20th week of pregnancy. J Endocrinol 1974;61:75-81.
  14. Human chorionic gonadotropin pattern in serum and its relation to the sex of the fetus. J Clin Endocrinol 1965;25:792-97.
  15. Fetal gender impact on multiple-marker screening results. Am J Med Genet 1998;76:369-71.
  16. Maternal serum human chorionic gonadotropin concentrations and fetal sex prediction. Fertil Steril 1980;34:336-40.
  17. The value of elevated second-trimester β-human chorionic gonadotropin in predicting development of preeclampsia. Am J Obstet Gynecol 1997 Feb;176(2):438-42.
  18. The predictive value of an initial serum beta-human chorionic gonadotropin level for pregnancy outcome following in vitro fertilization. J Assist Reprod Gen 1996;13:705-08.
  19. The predictive value of single beta-human chorionic gonadotropin in pregnancies achieved by assisted reproductive technology. Fertil Steril 1994;62:333-38.
  20. Predictive value of early serum beta-hCG levels after single blastocyst transfer. Act a Obstet Gynecol Scand 2009;88(12):1382-88.
  21. Delay of embryo transfer to day 5 results in decreased initial serum beta-human chorionic gonadotropin levels. Fertil Steril 2003 Dec;80(6):1359-63.
  22. Association between birth weight and first-trimester free beta-human chorionic gonadotropin and pregnancyassociated plasma protein A. Fertil Steril 2008 Jan;89(1):174-78. Epub 2007, May 16.
  23. Predicting complications of pregnancy with first-trimester maternal serum free-β-hCG, Nataša PAPP-A and inhibin-A. Prenatal Diagnosis 2003 Dec. Z. Predicting complications of pregnancy with first-trimester maternal serum free-β-hCG, Nata. a PAPP-A and inhibin-A. Prenatal Diagnosis 2003 Dec 15;23(12):990-96.
  24. First trimester maternal serum free beta-human chorionic gonadotropin and pregnancy associated plasma protein A as predictors of pregnancy complications. Br J Obstet Gynaecol 2000;107: 1265-70.
  25. Serum beta human chorionic gonadotropin levels can inform outcome counseling after in vitro fertilization. Fertility and Sterility 2011 Aug; 96(2):505-07.
  26. Early maternal serum β-human chorionic gonadotropin measurements after ICSI in the prediction of long-term pregnancy outcomes: A retrospective cohort analysis. J Clin Med Res, ISSN 1918-3003 Print, 2011 Feb;3(1):30-35.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.