International Journal of Infertility & Fetal Medicine

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VOLUME 3 , ISSUE 1 ( January-April, 2012 ) > List of Articles


Social Isolation Following Embryo Transfer increases Success Rates in IVF and ICSI Cycles

Anu Kottur, Muthugadhahalli S Srinivas, Partha P Majumdar, Pushpa M Bhargava

Citation Information : Kottur A, Srinivas MS, Majumdar PP, Bhargava PM. Social Isolation Following Embryo Transfer increases Success Rates in IVF and ICSI Cycles. Int J Infertil Fetal Med 2012; 3 (1):8-14.

DOI: 10.5005/jp-journals-10016-1033

License: CC BY-NC 4.0

Published Online: 01-12-2014

Copyright Statement:  Copyright © 2012; The Author(s).


Background and objective

Bruce et al had shown, during 1959 to 1968, that if, 24 hours after mating, a mouse belonging to a different inbred strain than the stud mouse was placed in the cage of the female mouse, partitioned in such a way that no physical contact of the nonstud male with the female was possible, pregnancy was blocked. We, therefore, decided to determine whether, by analogy with mice, isolation of women from all other men except the husband, for 3 days after embryo transfer following in vitro fertilization (IVF) or intracycloplasmic sperm injection (ICSI), increases the establishment of pregnancy.


We isolated randomly selected 729 women from all other men except the husband for 3 full days after embryo transfer following IVF/ICSI, and followed them to the end of pregnancy; 1005 randomly selected women who were treated similarly but not isolated served as the control group.


The establishment of clinical pregnancy as well as live births were more than 50% higher in the isolated group than in the control.


The social isolation as mentioned above could substantially increase the success rates in IVF or ICSI. While the exact mechanism of this phenomenon is yet to be understood, one possible explanation may be, by analogy with mice, an olfactory block to implantation.

How to cite this article

Rao KA, Srinivas MS, Kottur A, Majumdar PP, Bhargava PM. Social Isolation Following Embryo Transfer Increases Success Rates in IVF and ICSI Cycles. Int J Infertility Fetal Med 2012;3(1):8-14.

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  1. Assisted reproductive technology in Europe 2000. Results generated from European registers by Eshre. Hum Reprod 2004;19:490-503.
  2. Cumulative live birth rates in cohorts of patients treated with in vitro fertilization or intracytoplasmic sperm injection. Fertil Steril 2005;84:99-107.
  3. Cumulative live-birth rates after in vitro fertilization. New Engl J Med 2009;360: 236-43.
  4. Pregnancy and birth rates after oocyte donation. Fertil Steril 1997;67:717-23.
  5. Conception to ongoing pregnancy: The black box of early pregnancy loss. Hum Reprod Update 2002;8:333-43.
  6. High rates of embryo wastage with use of assisted reproductive technology: A look at the trends between 1995 and 2001 in the United States. Fertil Steril 2005;84:325-30.
  7. An exteroceptive block to pregnancy in mouse. Nature 1959;184:105.
  8. Absence of pregnancy-block in mice when stud and test males belong to an inbred strain. J Reprod Fertil 1968;17: 407-08.
  9. Olfactory stimuli in mammalian reproduction. Science 1961;134:1049-54.
  10. Oestrous synchronization and pregnancy blocking in wild house mice (Mus musculus). J Reprod Fertil 1966;12:233-36.
  11. Mice: Individual recognition by olfactory cues. Science 1969;158:1208-10.
  12. Evolution and comparative genomics of odorant- and pheromone-associated genes in rodents. Genome Res 2004;14:591-602.
  13. Early cleavage predicts the viability of human embryos in elective single embryo transfer procedure. Hum Reprod 2003;18:821-25.
  14. Suppression of the endogenous luteinizing hormone surge by the gonadotrophin-releasing hormone antagonist cetrorelix during ovarian stimulation. Hum Reprod 1994;9:788-91.
  15. Among patients treated for IVF with gonadotrophins and GnRH analogues, is the probability of live birth dependent on the type of analogue used? A systematic review and meta-analysis. Hum Reprod Update 2006;12: 651-71.
  16. Pregnancy rate fluctuations during routine work in an assisted reproduction technology unit. Hum Reprod 2003;18: 2485-88.
  17. The fantastic power of smell signals that permeate our environment. Do human pheromones exist? Sci Reporter 1994;31(11):24-27.
  18. Fifty years of pheromones. Nature 2009;457: 262-63.
  19. Studies of HLA, fertility and mate choice in a human isolate. Hum Reprod Update 1999;5:103-07.
  20. MHC-correlated odour preferences in humans and the use of oral contraceptives. Proc Roy Soc B 2008;275:2715-22.
  21. Comparison of assisted reproductive technology utilization and outcomes between Caucasian and African American patients in an equal-access-to-care setting. Fertil Steril 2006;85:888-94.
  22. Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Cell 2005;123: 669-82.
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