International Journal of Infertility & Fetal Medicine

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VOLUME 2 , ISSUE 3 ( September-December, 2011 ) > List of Articles

RESEARCH ARTICLE

Abdominal Fat Distribution, Insulin Resistance and Cardiovascular Risk Profiles in Women with Polycystic Ovary Syndrome

Reshma Sultana, Lakshmi Rathna Marakani, Sirisha Rao Gundabattula

Citation Information : Sultana R, Marakani LR, Gundabattula SR. Abdominal Fat Distribution, Insulin Resistance and Cardiovascular Risk Profiles in Women with Polycystic Ovary Syndrome. Int J Infertil Fetal Med 2011; 2 (3):106-108.

DOI: 10.5005/jp-journals-10016-1028

Published Online: 00-12-2011

Copyright Statement:  Copyright © 2011; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim

To determine potential associations of abdominal fat distribution with insulin resistance and cardiovascular risk in women with polycystic ovary syndrome (PCOS).

Methods

Cross-sectional study that included detailed clinical examination, body mass indices (BMI), waist-hip ratio, insulin resistance and cardiovascular risk scores for 350 women registered between August 2008 and December 2009. Biochemical analysis included fasting blood glucose level, serum insulin level, triglycerides, total cholesterol and HDL cholesterol. Primary outcomes of interest included insulin resistance and cardiovascular risk score.

Results

The mean age of the subjects was 25.77 years. Oligoovulation was present in 99% of the women. Eighty-two (23.43%, 95% CI: 19.21%, 28.08%) women were obese and 100 (28.57%, 95% CI: 24.02%, 33.47%) women had android obesity. Insulin resistance was present in 136 (38.86%, 95% CI: 33.85%, 44.05%) women and 107 (30.57%, 95% CI: 25.91%, 35.55%) women had a cardiovascular risk >1. Women with a waist-hip ratio >0.85 were more likely to have insulin resistance (OR 2.70, 95% CI: 1.68, 4.35, p < 0.001) and at increased risk for cardiovascular events (OR: 1.82, 95% CI: 1.12, 2.97, p = 0.02). Obese women were more likely to have insulin resistance (OR 2.53, 95% CI: 1.53, 4.19, p < 0.001) and at increased risk for cardiovascular events (OR: 2.17, 95% CI: 1.30, 3.63, p = 0.003).

Conclusion

Long-term health hazards of PCOS have to be considered as these may be prevented to some extent by early identification and interventions, such as changing the lifestyle of the individual.


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  1. Abdominal fat quantity and distribution in women with PCOS and extent of its relation to insulin resistance. J Clin Endocrinol Metab 2007;92:2500-07.
  2. Internal carotid artery response to 5% CO2 in women with polycystic ovaries. Lancet 2000;356:1166-67.
  3. Altered vascular function in young women with PCOS. J. Clin Endocrinol Metab 2002;85:1851-56.
  4. Evidence for association between PCOS and premature carotid atherosclerosis in middleaged women. Arterioscler Thromb Vasc Biol 2000;20:2414-21.
  5. Diabetes prevalence and risk factors in polycystic ovary syndrome. Obstet Gynecol Clin N Am 2001;28:99-109.
  6. Role of obesity and insulin in the development of anovulation. In: Filicori M, Flamignic, (Eds), Ovulation induction: Basic science and clinical advances. Amsterdam: Elsevier Science Br 1994;103-14.
  7. A direct effect of hyperinsulinaemia on serum SHBG levels in obese women with PCOS. J Clin Endocrinol Metab 1991;72:83-89.
  8. PCOS and CVD. A premature association. Endocrine Reviews 2003- 2004;24:302-12.
  9. Hyperandrogenic anovulation (PCOS): A unique disorder of insulin action associated with an increased of noninsulin dependant diabetes mellitus. Am J Med 1995;98:335.
  10. Relationship of androgenic activity of body fat topography, fat cell morphology and metabolic aberrations in premenopausal women. J Clin Endocrinol Metab 1983;57;304-10.
  11. Polycystic ovary syndrome: The spectrum of the disorder in 1741 patients. Hum Reprod 1995;10:2107-11.
  12. Waist circumference, waist-hip ratio and body mass index and their correlation with cardiovascular disease risk factors in Australian adults. Journal of Internal Medicine 2003;254:555-63.
  13. Waist circumference and waist-hip ratio as predictors of cardiovascular events. Meta regression and analysis. European Heart Journal 2007;28:850-56.
  14. PCOS. New England Journal of Medicine 1995;333: 853-61.
  15. The epidemiology of polycystic ovary syndrome, prevalence and associated disease risks. Endocrinal Metab Clin N Am 1999;28(2);247-63.
  16. Body fat distribution and the risk of coronary heart disease in men and women in the European prospective investigation into cancer and nutrition in Norfolk cohort. Circulation 2007;116:2933-43.
  17. Article on FBS and Insulin ratio less than 4.5. Archives of Iranian Medicine 2007;10(2):176-81.
  18. Dyslipidemia is associated with insulin resistance in women with polycystic ovaries. Clin Endocrinol (Oxf) 1996;44:277-84.
  19. The current understanding of polycystic ovary syndrome. The Obstetrician and Gyanecologist 2004;6(2): 66-74.
  20. Infertility in Berek and Novak's Gynecology (14th ed). Lippincott Williams and Wilkins USA 2007:1185-276.
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