This study was conducted to determine the efficacy of using the technique of intracytoplasm morphologically selected sperm injection (IMSI) as compared to the conventionally used intracytoplasmic sperm injection ((ICSI) procedure. IMSI, as the name suggests, is the technique of selecting the most normal looking sperm by magnifying it to about 7200 times. A total of 192 patients who underwent the treatment of in vitro fertilization (IVF) with us by either one of the two procedures of IMSI or ICSI over a period of 18 months were included in the study. Out of these 92 were included in the IMSI group while 100 others in the ICSI group according to our inclusion and exclusion criteria. The pregnancy rate among patients who underwent IMSI was found to be significantly higher (52.1%) as compared to those with ICSI (36%). Furthermore, even the implantation rates were higher in the IMSI group (30.12%) than the ICSI (19.93%) group.
Real-time fine morphology of motile human sperm cells is associated with IVF-ICSI outcome. Journal of Andrology 2002;23:1-8.
Predictive value of sperm morphology in in vitro fertilization. Fertility and Sterility 1988;49:112-17.
Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection. Fertility and Sterility 2003;80:1413-19.
Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte. Lancet 1992;340:17.
Sperm morphological features as a prognostic factor in IVF. Fertility and Sterility 1986;46:1118-23.
New method of evaluating sperm morphology with predictive value for human in vitro fertilization. Urology 1987;3:248-51.
Influence of sperm parameters on embryo quality. Fertility and Sterility 1993;60:888-92.
In vitro fertilization and pregnancy rates: The influence of sperm motility and morphology on IVF outcome. Fertility and Sterility 1998;70: 305-14.
Semen parameters in a fertile versus subfertile population: A need for change in the interpretation of semen testing. Human Reproduction 1997;12:987-93.
Pregnancy after transfer of sperm under zona. Lancet 1988;2:790.
Twin birth after subzonal insemination. Lancet 1990;335: 722-23.
The RAPRUI. Center experience: From SUZI, through lasers to ICSI using spermatozoa with broken tails. Human Reproduction 1995;10:489-91.
The result of intracytoplasmic sperm injection is not related to any of the three basic sperm parameters. Human Reproduction 1995;10:1123-29.
The outcome of intracytoplasmic sperm injection is unrelated to ‘strict criteria’ sperm morphology Human Reproduction 1996;11(5):1019-22.
The effect of sperm parameters on the outcome of intracytoplasmic sperm injection. Fertil Steril 1995;64: 982-86.
Semen quality: Is there a paternal effect on pregnancy outcome in in vitro fertilization/intracytoplasmic sperm injection? Hum Reprod 1998;13:2161-64.
Fertility of ejaculated and testicular megalohead spermatozoa with intracytoplasmic sperm injection. Human Reproduction 1999;14:726-30.
The effect of intracytoplasmic sperm injection and semen parameters on blastocyst development in vitro. Human Reproduction 2001;16:918-24.
Influence of individual sperm morphology on fertilization, embryo morphology, and pregnancy outcome of intracytoplasmic sperm injection. Fertility and Sterility 2003;79:42-48.
Does the presence of nuclear vacuoles in human sperm selected for ICSI affect pregnancy outcome? Human Reproduction 2006a;21:1787-90.
How to improve IVF-ICSI outcome by sperm selection. Reproductive BioMedicine Online 2006b;12:634-38.
Intracytoplasmic sperm injection: Achievement of high pregnancy rates in couples with severe male factor infertility is dependent primarily upon female not male factors. Fertility and Sterility 1995;64:977-81.
Ultrastructure of gametes and intracytoplasmic sperm injection: The significance of sperm morphology. Human Reproduction 1998;13 (Suppl 1):99-106.
Morphology of spermatozoa used in IVF and ICSI from oligozoospermic men. Reproductive BioMedicine Online 2001;3:212-15.
Sperm selection for ICSI: Shape properties do not predict the absence or presence of numerical chromosomal aberrations. Human Reproduction 2004;19:2052-59.
Effect of abnormal sperm head morphology on the outcome of intracytoplasmic sperm injection in humans. Human Reproduction 1997;12:1214-17.
Pregnancy outcome of in vitro fertilization/ intracytoplasmic sperm injection with profound teratospermia. Fertility and Sterility 2004;82:847-49.
The outcome of clinical pregnancies following intracytoplasmic sperm injection is not affected by semen quality. Andrologia 1998;30:91-95.
Assessment of the dominant abnormal form is useful for predicting the outcome of intracytoplasmic sperm injection in case of severe teratozoospermia. J Assist Reprod genet. 1999;16:436-42.
