International Journal of Infertility & Fetal Medicine

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VOLUME 2 , ISSUE 1 ( January-April, 2011 ) > List of Articles


Unsuspected Acquired Hemophilia in a Patient with Severe Postpartum Hemorrhage

Yeshita V Pujar, Bhavana Y Sherigar, Shobhana Patted, BR Desai, Jayashree Ruge

Citation Information : Pujar YV, Sherigar BY, Patted S, Desai B, Ruge J. Unsuspected Acquired Hemophilia in a Patient with Severe Postpartum Hemorrhage. Int J Infertil Fetal Med 2011; 2 (1):41-43.

DOI: 10.5005/jp-journals-10016-1016

License: CC BY-NC 4.0

Published Online: 01-04-2014

Copyright Statement:  Copyright © 2011; The Author(s).


A 24-year-old healthy multigravid patient developed postpartum hemorrhage 3 days post normal delivery. She underwent curettage × 3 followed by laparotomy and hysterectomy. Postoperatively she developed a subrectus hematoma that required laparotomy and drainage. Persistent bleeding per vaginum prompted a third laparotomy for internal iliac ligation, which could not be carried out due to massive retroperitoneal hematoma. She received multiple transfusions of blood and blood products. Her APTT was prolonged but DIC screen was negative. Prolonged APTT was not corrected by addition of normal plasma. This pointed to autoantibodies to factor VIII. She responded to immunosuppression with prednisolone and cyclophosphamide.

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