International Journal of Infertility & Fetal Medicine

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VOLUME 15 , ISSUE 1 ( January-April, 2024 ) > List of Articles


Comparison of Fresh vs Frozen Embryo Transfer in Terms of Early Pregnancy Outcome

Minakshi Pounikar, Priyal Shrivastava

Keywords : Assisted reproduction technique, Early pregnancy loss, Fresh embryo transfer, Thawed embryos

Citation Information : Pounikar M, Shrivastava P. Comparison of Fresh vs Frozen Embryo Transfer in Terms of Early Pregnancy Outcome. Int J Infertil Fetal Med 2024; 15 (1):58-61.

DOI: 10.5005/jp-journals-10016-1339

License: CC BY-NC 4.0

Published Online: 29-02-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Aims and background: Recently, storing all embryos has become a new dictum of improving the overall success of in vitro fertilization (IVF); however, contradictory data is found in the literature, especially about its impact on early loss of pregnancy in comparison to the practice of fresh transfer of embryos. In this study, we tried to analyze early pregnancy loss as a primary outcome along with total live births as a secondary outcome among selected women undergoing fresh and frozen embryo transfer (FET). Materials and methods: In this prospective observational study, 60 consecutive women seeking IVF treatment for fresh/FET were recruited. Within group I, fresh, and in group II, FET was done. The main outcome parameter was early pregnancy loss. Student's t-test was implemented, and calculation was done using the p-value. Results: In group I, early pregnancy loss was 10%, out of which 3.3% were chemical pregnancies, 3.33% were missed abortions, 3.3% were complete abortions, and live births were 33.3%. In group 2, 30% could not continue till 20 weeks. Around 6.66% were chemical pregnancies, 3.33% had blighted ovum, 6.66% with no cardiac activity, 3.33% missed abortion at 7–9 weeks, 3.33% at >9–11 weeks, and 6.66% second-trimester abortions. Live births achieved were 43.3%. Conclusion: Fresh embryo transfer is associated with a lower miscarriage rate (MR), that is, 10%, but a lesser live birth rate (LBR), that is, 33.3%, than frozen-thawed embryo transfer, where it is 30% and 43.3%, respectively. Clinical significance: On the basis of this study, it can be stated that early pregnancy losses are more in frozen cycles against fresh transfer; however, statistically, the difference is nonsignificant.

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