International Journal of Infertility & Fetal Medicine

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VOLUME 15 , ISSUE 1 ( January-April, 2024 ) > List of Articles


Effect of Physical Activity on Markers of Insulin Resistance in Infertile Women with Polycystic Ovary Syndrome

Meera Shivasekar, Arul Senghor Kadalangudi Aravaanan, Vinodhini Vellore Mohanakrishnan, Anuradha Murugesan

Keywords : Adiponectin, Homeostatic Model Assessment-adiponectin, Metabolic equivalents of task, Physical activity 150 minutes/week, Resistin

Citation Information : Shivasekar M, Aravaanan AS, Mohanakrishnan VV, Murugesan A. Effect of Physical Activity on Markers of Insulin Resistance in Infertile Women with Polycystic Ovary Syndrome. Int J Infertil Fetal Med 2024; 15 (1):26-30.

DOI: 10.5005/jp-journals-10016-1331

License: CC BY-NC 4.0

Published Online: 29-02-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Objective: Regular physical activity (PA) regulates important interactive pathways linking energy balance, neuroendocrine function, and hypothalamic pituitary ovarian axis. Consistent physical activities are known to improve insulin sensitivity which exerts its effects via adipokines. The purpose of the study is to determine insulin resistant (IR) status and the effect of brisk walking on the levels of adipocytokines in women with polycystic ovarian syndrome (PCOS). Design: It is a prospective study. Materials and methods: The study included 143 married women with PCOS (as per Rotterdam's criteria) and 110 married women as controls with at least one child through natural conception. Anthropometric measurements were documented. Adiponectin and resistin were analyzed. Homeostatic Model Assessment of IR (HOMA-IR) and HOMA-adiponectin were calculated to assess IR. A follow-up task of 150 minutes/week of PA of brisk walking of moderate intensity was advised for 12 weeks and the status was reassessed. Results: Infertile women with PCOS, hypoadiponectinemia, and hyperesistinemia with elevated markers of IR (HOMA-IR and HOMA-adiponectin) were observed. The baseline data were compared with estimates after 12 weeks, it was found that adiponectin levels were increased with 4.75% weight loss, and decreased levels of resistin, HOMA-IR, and HOMA-adiponectin were observed. Participants who met 150 minutes/week of brisk walking revealed an increase in adiponectin levels and a strong positive correlation (r = 0.76) was observed with regression analysis of metabolic equivalents of tasks (METs) PA with adiponectin levels. Diagnostic sensitivity and specificity of adiponectin at a cutoff value of 7.3 µg/mL with 150 minutes/week of PA were found to be 93.8 and 82.1%, respectively. It was observed a 16.6% reduction of HOMA-IR and 29% of HOMA-adiponectin in the women who completed 12 weeks of PA had statistically significant p-values. An ovarian follicular study revealed positive ovulation in 80% of the participants with >150 minutes/week of brisk walking. Conclusion: Brisk walking of 150 minutes/week resulted in increased adiponectin levels. Beneficial adiponectin facilitates the ovulatory menstrual cycle and thereby the chance of ovulation is increased in PCOS women.

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