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VOLUME 14 , ISSUE 2 ( May-August, 2023 ) > List of Articles
PV Aishwarya, Sahana Sreenivas, SK Manjula
Keywords : Case report, Consanguineous, Neurodevelopmental, Pregnancies
Citation Information : Aishwarya P, Sreenivas S, Manjula S. Recurrent Neurodevelopmental Disorders in Subsequent Pregnancies in a Couple with Third-degree Consanguineous Marriage: Case Report. Int J Infertil Fetal Med 2023; 14 (2):105-107.
License: CC BY-NC 4.0
Published Online: 12-05-2023
Copyright Statement: Copyright © 2023; The Author(s).
Introduction: There is a poor understanding of the molecular mechanisms of neurodevelopmental and metabolic morbidity affecting the fetus in pregnancy. Case description: The case has two living children, born of a third-degree consanguineous marriage, both affected by neurodevelopmental disorders. Studies have shown maternal inflammation in pregnancy was attributed to increased neurodevelopmental disorders in the baby. Subclinical inflammation in our patient was seen by histopathology of the placenta showing maternal inflammatory response stage-I grade-I. Other multifactorial causes should be evaluated preconceptionally. Subclinical inflammation in our patient, as seen by histopathology of the placenta, shows maternal inflammatory response stage-I grade-I. Conclusion: Follow-up of the baby prompt antepartum surveillance, along with postnatal metabolic screening for neurodevelopmental diseases, needs to be stressed to detect any central nervous system (CNS) abnormalities in the present pregnancy.