Citation Information :
Gupta P, Agrawal S, Agarwal A, Pandey A, Kumar N, Ali W. Comparison of Endocrine and Metabolic Profile of Obese and Lean PCOS Women with Infertility. Int J Infertil Fetal Med 2022; 13 (3):125-128.
Background: Polycystic ovary syndrome (PCOS) has been associated with endocrine and metabolic abnormalities. The study’s objective was to compare the endocrine and metabolic parameters of lean and obese PCOS women with infertility.
Materials and methods: After satisfying the inclusion and exclusion criteria, infertile women with PCOS were enrolled in the study. Women were divided into two groups according to their body mass index (BMI); group I with BMI <23 kg/m2 (lean and underweight) and group II with BMI ≥ 23 kg/m2 (obese and overweight) according to the Indian Council of Medical Research (ICMR) guidelines. Physical characteristics like the presence of acne, hirsutism, acanthosis nigricans (AN), and waist–hip ratio (WHR) were noted in all. The endocrine profile included serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), anti-Müllerian hormone (AMH), thyroid-stimulating hormone, prolactin, estradiol, and testosterone, while the metabolic profile included lipid profile, oral glucose tolerance test (OGTT) (fasting and 2 hours), fasting insulin.
Results: A total of 80 women were enrolled. Obese PCOS had hypertriglyceridemia (15% vs 0% in lean group, p = 0.011) and hypercholesterolemia (20% vs 2.5%, p = 0.011). AN, acne, hirsutism, hormonal profile (LH/FSH ratio, AMH, serum testosterone), fasting insulin, and OGTT were similar in both groups.
Conclusion: Increased BMI in PCOS women is associated with increased WHR and altered lipid profile with no difference in endocrine parameters.
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