International Journal of Infertility & Fetal Medicine

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VOLUME 13 , ISSUE 1 ( January-April, 2022 ) > List of Articles


Occurrence of Insulin Resistance with Recurrent Pregnancy Loss of Unknown Etiology in North Indian Hospital-based Women Population: A Pilot Study

Harpreet Singh, Anubhuti Chitkara, Jayashree Bhattacharjee

Keywords : HOMA-IR, Insulin resistance, Pregnancy outcome, Recurrent pregnancy loss (RPL), Unexplained etiology

Citation Information : Singh H, Chitkara A, Bhattacharjee J. Occurrence of Insulin Resistance with Recurrent Pregnancy Loss of Unknown Etiology in North Indian Hospital-based Women Population: A Pilot Study. Int J Infertil Fetal Med 2022; 13 (1):15-17.

DOI: 10.5005/jp-journals-10016-1256

License: CC BY-NC 4.0

Published Online: 19-01-2022

Copyright Statement:  Copyright © 2022; The Author(s).


Objective: Recurrent pregnancy loss (RPL) has been defined as occurrence of two or more clinically recognized spontaneous consecutive pregnancy losses prior to the 20th gestational weeks according to new guidelines of the American Society of Reproductive Medicine. Although multiple factors have been explained for RPL but still in most of the cases no etiology is found. Study design: It was a prospective analytical observational study. It was conducted on 100 nonpregnant women in reproductive age-group 20–30 years, 50 women, with history of two or more consecutive spontaneous abortions in study group and 50 women with at least one live birth and no history of recurrent abortions in control group. These two groups were matched for age and BMI. All the women underwent various examinations like ultrasound pelvis for ruling out any uterine anomaly, hysteroscopy, antiphospholipid profile, hormonal profile, screening for DM, and thyroid disorders, HOMA–IR was calculated for insulin resistance. Result: A significant difference (<0.0001) was observed in fasting blood sugar and serum insulin levels in the case and control groups (<0.0005). HOMA–IR was also found to be significantly increased in RPL group (p ≤ 0.0005). Conclusion: Insulin resistance and hyperinsulinemia may be an important risk factor in women with idiopathic RPL.

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