International Journal of Infertility & Fetal Medicine

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VOLUME 12 , ISSUE 3 ( September-December, 2021 ) > List of Articles


Hypothyroidism and Hyperprolactinemia as a Cause of Primary Infertility: A Single Center Study

Nihida Akhter, Asma Khanday, Irfan N Mir

Keywords : Hyperprolactinemia, Primary infertility, Thyroid-stimulating hormone

Citation Information : Akhter N, Khanday A, Mir IN. Hypothyroidism and Hyperprolactinemia as a Cause of Primary Infertility: A Single Center Study. Int J Infertil Fetal Med 2021; 12 (3):66-68.

DOI: 10.5005/jp-journals-10016-1222

License: CC BY-NC 4.0

Published Online: 30-09-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Introduction: Infertility is a common condition, with important medical economic and psychological implications. We have observed a surge in cases of primary infertility in our OPD of late. Hypothyroidism and hyperprolactinemia have been implicated as a cause of primary infertility. Materials and methods: We conducted a prospective cross-sectional study in our hospital, Government Medical College, on an OPD basis, between May 2017 and January 2019, to check for hypothyroidism and hyperprolactinemia as a cause of primary infertility among females, after ruling out other common implicated factors that may be the cause of infertility. We labeled the study group as group I and the control group as group II. Results: The mean age of patients in group I was 26.21 years, and that in group II was 25.63 years, respectively. The average time since marriage in group I was found to be 1.67 years and that in group II was 1.78 years, respectively. The rural–urban ratio of patients in group I was 23:27 and that in group II was 34:16. The mean TSH level in group I was found to be 7.11 ± 1.91 and that in group II was found to be 3.28 ± 2.11. The mean levels of serum prolactin in group I were 41.62 ± 20.02 and that in group II were 22.36 ± 15.61, respectively. There was a high prevalence of hypothyroidism and hyperprolactinemia in group I when compared with group II. Conclusion: This study showed significantly higher prolactin and TSH levels among the primary infertile female patients. Therefore, for proper management of infertile cases, it may be necessary to look for thyroid dysfunction and treat it accordingly.

  1. Micinsk P, Wielgus E, Wojcieszyn M, et al. Abnormal ovarian reserve test reflects thyroid dysfunction. Pol J Gyn Invest 2006;9(1):30–34.
  2. AL-Mawajdeh IE. Correlation of thyroid hormones, gonadotropins and age in infertile women in the south of Jordan. Eur J Sci Res 2011;63:219–230.
  3. Turankar S, Sonone K, Turankar A. Hyperprolactinaemia and its comparison with hypothyroidism in primary infertile women. J Clin Diagn Res 2013;7(5):794–796. DOI: 10.7860/JCDR/2013/4878.2941.
  4. Frey KA, Patel KS. Initial evaluation and management of infertility by the primary care physicians. Mayo Clin Proc 2004;79(11):1439–1443. DOI: 10.4065/79.11.1439.
  5. Binita G, Suprava P, Mainak C, et al. Correlation of prolactin and thyroid hormone concentration with menstrual patterns in infertile women. J Reprod Infertil 2009;10(3):207–212.
  6. Southam AL. What to do with the normal infertile couple. Fertile Sterile 1960;11(6):543. DOI: 10.1016/S0015-0282(16)33969-3.
  7. Patel SS, Bamigboye. Hyperprolactinemia. J Obstet Gynecol 2007;27(5):455–459. DOI: 10.1080/01443610701406125.
  8. Bals-Pratsch M, De Geyter C, Muller T, et al. Episodic variations of prolactin, thyroid-stimulating hormone, luteinizing hormone, melatonin and cortisol in infertile women with subclinical hypothyroidism. Hum Reprod 1997;12(5):896–904. DOI: 10.1093/humrep/12.5.896.
  9. Freundl G, Godehardt E, Kern PA, et al. Estimated maximum failure rates of cycle monitors using daily conception probabilities in the menstrual cycle. Hum Reprod 2003;18(12):2628–2633. DOI: 10.1093/humrep/deg488.
  10. Sridevi N, Sandhya Rani M. Study of thyroid profile in infertile women. IOSR J Pharm Biol Sci 2015;10(3):57–61.
  11. Koutras DA. Disturbances of menstruation in thyroid disease. Ann N Y Acad Sci 1997;816(1 Adolescent Gy):280–284. DOI: 10.1111/j.1749-6632.1997.tb52152.x.
  12. Cramer DW, Sluss PM, Powers RD, et al. Serum prolactin and TSH in an in vitro fertilization population: is there a link between fertilization and thyroid function? J Assist Reprod Genet 2003;20(6):210. DOI: 10.1023/a:1024151210536.
  13. Poppe K, Velkeniers B. Thyroid and infertility. Verh K Acad Geneeskd Belg 2002;64(6):389–399.
  14. Kumkum A, Kaur J, Gupta S, et al. Hyperprolactinemia and its correlation with hypothyroidism in infertile woman. ObstetGynecol India 2005;56:68–71.
  15. Valvekar U, Viswanathan S. Prevalence of hyperprolactinaemia and hypothyroidism in primary and secondary infertility women. J Med Sci Tech 2016;5(2):8–13.
  16. Mishra R, Baveja R, Gupta V. Prolactin levels in infertility with menstrual irregularities. J Obstet Gynecol India 2002;52:40–43.
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