International Journal of Infertility & Fetal Medicine

Register      Login

VOLUME 12 , ISSUE 2 ( May-August, 2021 ) > List of Articles

Original Article

Development and Formulation of Phytoestrogen-rich Supplement for Women with Polycystic Ovary Syndrome

Gayathri Kalidoss, Supriya Velraja, Palaniappan Narayanan

Citation Information : Kalidoss G, Velraja S, Narayanan P. Development and Formulation of Phytoestrogen-rich Supplement for Women with Polycystic Ovary Syndrome. Int J Infertil Fetal Med 2021; 12 (2):31-36.

DOI: 10.5005/jp-journals-10016-1221

License: CC BY-NC 4.0

Published Online: 29-07-2021

Copyright Statement:  Copyright © 2021; The Author(s).


Background: Polycystic ovary syndrome (PCOS) is an endocrine disorder with various health complications like menstrual irregularities, hirsutism, acne, obesity, and insulin resistance. It is becoming a prominent cause of infertility among women worldwide. A woman's diet may ultimately affect her fertility, particularly ovulation. The assisted reproductive technologies for the treatment of infertility may cost high and have an adverse effect. To reduce the adverse effects, the novel dietary supplements are the new alternative approach to treat PCOS. Novel dietary supplements enriched with phytoestrogen help in alleviating the symptoms of PCOS such as improvement in ovulation, reduced blood glucose level, reduced stress level, and decreased weight. The present study was aimed to develop novel dietary supplements for women with PCOS. Aim and objective: To develop novel dietary supplements for women with PCOS by using underutilized ingredients. Materials and methods: Three different types of novel dietary supplements (supplement 1, supplement 2, and supplement 3) were developed under proper hygienic conditions. The organoleptic properties of the developed supplements were evaluated by the group of panel members. Followed by organoleptic evaluation, nutrient compositions were analyzed for the finalized supplement (supplement 3). Results: The nutrient composition of the finalized supplement was analyzed by using the standard procedure of AOAC (2016) and it is reported that the supplement is enriched with omega-3-fatty acid, polyphenols, flavonoids, selenium, iron, vitamin-A, and fiber. One-way ANOVA was used to analyze the significance between the formulated supplements and reported that the formulated supplements were statistically significant (p < 0.05). Conclusion: The study signifies that novel dietary supplements rich in phytoestrogens like polyphenols and flavonoids can be used for the treatment of PCOS. Clinical significance: Intake of developed supplement could result in regulation of menstruation and improvement in ovulation.

  1. Norman RJ, Dewailly D, Legro RS, et al. Polycystic ovary syndrome. The Lancet 2007;370(9588):685–697. DOI: 10.1016/S0140-6736(07)61345-2.
  2. Livadas S, Diamanti-Kandarakis E. Polycystic ovary syndrome: definitions, phenotypes and diagnostic approach. In: Polycystic Ovary Syndrome, vol. 40. Karger Publishers; 2013. pp. 1–21.
  3. Amini L, Tehranian N, Movahedin M, et al. Antioxidants and management of polycystic ovary syndrome in Iran: a systematic review of clinical trials. Iranian J Reproduct Med 2015;13(1):1.
  4. Iliescu CA, Tarta-Arsene O, Craiu DA. Valproic acid, polycystic ovary syndrome and the adolescent with epilepsy. Farmacia 2017;65(1):1–4.
  5. Lim SS, Davies MJ, Norman RJ, et al. Overweight, obesity and central obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis. Human Reproduct Update 2012;18(6):618–637. DOI: 10.1093/humupd/dms030.
  6. Diamanti-Kandarakis E, Dunaif A. Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr Rev 2012;33(6):981–1030. DOI: 10.1210/er.2011-1034.
  7. Pastore LM, Patrie JT, Morris WL, et al. Depression symptoms and body dissatisfaction association among polycystic ovary syndrome women. J Psychosoma Res 2011;71(4):270–276. DOI: 10.1016/j.jpsychores.2011.02.005.
  8. Kazemi M, McBreairty LE, Zello GA, et al. A pulse-based diet and the therapeutic lifestyle changes diet in combination with health counseling and exercise improve health-related quality of life in women with polycystic ovary syndrome: secondary analysis of a randomized controlled trial. J Psychosoma Obstet Gynecol 2020;41(2):144–153. DOI: 10.1080/0167482X.2019.1666820.
  9. Choi HD, Kim JH, Chang MJ, et al. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytotherapy Res 2011;25(12):1813–1818. DOI: 10.1002/ptr.3494.
  10. Najafi MN, Kasaian J, Kovatsi L, et al. Phytoestrogens and the polycystic ovary syndrome: a systematic review of clinical evidence and laboratory findings. Farmacia 2018;66(2):223–229.
  11. Fenga C, Costa CH, Caruso E, et al. Current evidence on the protective effect of dietary polyphenols on breast cancer. Farmacia 2016;64(1):1–2.
  12. Gaffer GG, Elgawish RA, Abdelrazek HM, et al. Dietary soy isoflavones during pregnancy suppressed the immune function in male offspring albino rats. Toxicol Rep 2018;5:296–301. DOI: 10.1016/j.toxrep.2018.02.002.
  13. Shailajan S, Sayed N, Menon S, et al. A validated RP-HPLC method for quantitation of trigonelline from herbal formulations containing Trigonella foenum-graecum (L.) seeds. Pharmaceut Met 2011;2(3):157–160. DOI: 10.4103/2229-4708.90354.
  14. Craig WJ. Phytochemicals: guardians of our health. J Am Diete Associat 1997;97(10):S199–S204. DOI: 10.1016/s0002-8223(97)00765-7.
  15. Jelodar G, Masoomi S, Rahmanifar F. Hydroalcoholic extract of flaxseed improves polycystic ovary syndrome in a rat model. Iranian J Basic Med Sci 2018;21(6):645. DOI: 10.22038/IJBMS.2018.25778.6349.
  16. Zhou L, Lin X, Abbasi AM, et al. Phytochemical contents and antioxidant and antiproliferative activities of selected black and white sesame seeds. Bio Med Res Int 2016;2016:8495630. DOI: 10.1155/2016/8495630.
  17. Yavari M, Rouholamin S, Tansaz M, et al. Herbal treatment of oligomenorrhea with Sesamum indicum L.: a randomized controlled trial. Galen Med J 2016;5(3):114–121.
  18. Nazeerullah K, Sunil K, Pal SR, et al. A pharmacognostic and pharmacological overview on Caesalpinia bonducella.. Res J Pharmaceut, Biolog Chem Sci 2012;3(1):440–496.
  19. Manikandaselvi S, Vadivel V, Brindha P. Caesalpinia bonducella L.: A nutraceutical plant. J Chem Pharm Res 2015;7(12):137–142.
  20. Moon K, Khadabadi SS, Deokate UA, et al. Caesalpinia bonducella F-an overview. Rep Opin 2010;2(3):83–90.
  21. Gaggat U, Sethi N, Singh K, Research Paper Open Access.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.