International Journal of Infertility & Fetal Medicine

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VOLUME 1 , ISSUE 1 ( September-December, 2010 ) > List of Articles

RESEARCH ARTICLE

Maternal and Perinatal Outcome in Pregnancies Following Infertility

Chitra Thyagarajan, Papa Dasari

Citation Information : Thyagarajan C, Dasari P. Maternal and Perinatal Outcome in Pregnancies Following Infertility. Int J Infertil Fetal Med 2010; 1 (1):25-29.

DOI: 10.5005/jp-journals-10016-1004

License: CC BY-NC 4.0

Published Online: 01-12-2010

Copyright Statement:  Copyright © 2010; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Context

General practitioners as well as obstetricians are coming across a large number of pregnant women whose conceptions are following a period of infertility or treatment for the same. There is a controversy in the literature regarding the occurrence of adverse outcomes of pregnancy in such women.

Aims

To assess the maternal and perinatal outcome in pregnancies that occurred after a period of infertility and to compare the outcome in spontaneous conceptions with the conceptions following treatment for infertility

Settings and Design

Retrospective analysis of hospital records of 200 pregnancies following infertility during the year 2009 in a tertiary care center in South India.

Material and Methods

All the women were divided into two groups, viz: Group 1—those who had history of infertility but conceived spontaneously and Group 2—those with history of infertility and conceived only after treatment for infertility. The main outcome measures were antenatal complications and adverse neonatal complications.

Statistical analysis

The statistical package SSPS version 15.0. Chi-square and student ‘t’ test was used for nonparametric and parametric variables.

Results

The incidence of hypertension was 60% and that of gestational diabetes was 7%. Obstetric complications included increased incidence of preterm labor (23.5%) and premature rupture of membranes (38%). There was no statistically significant difference in both groups though the medical complications especially hypertension was high in the pregnancies following spontaneous conceptions, i.e. untreated group. There was a greater demand for the NICU care mainly because of prematurity. The PNMR was (40/1000) less than the institutional rate of 72/1000 births.

Conclusions

There is increased incidence of hypertension premature rupture of membranes and preterm delivery in pregnancies following infertility. There is no significant statistical difference in the adverse pregnancy outcomes between spontaneous conception and those treated for infertility.

Key Messages

Pregnancies following infertility are at increased risk of developing hypertension and preterm labor and hence these women should be screened for the same and preventive measures to be undertaken to achieve good maternal and perinatal outcome.


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  1. Review of unexplained Infertility and obstetric outcome. Hum Reprod 2001;12:2593-97.
  2. Obstetric outcome in women with subfertility. Br J Obstet Gynecol 2005;112:632-37.
  3. Complications of pregnancy in infertile couples: Routine treatment versus assisted reproduction. Obstetrics and gynecology 1990;75:790-94.
  4. Obstetric outcome in patients with unexplained infertility: Comparision of treatment related and spontaneous pregnancies. Acta Obstet Gynecol Scand 1998;77:849-53.
  5. Adverse obstetric outcome in women with a history of infertility: A retrospective study. J Obstet Gynecol 2000;26:35-36.
  6. Complications and outcome of pregnancy in infertile PCOS patients. IJNMR 2007;12(3): 101-05.
  7. Pregnancy in infertile PCOD patients. Complications and outcome. J Reprod Med 1997;42:501-05.
  8. The obstetric and neonatal outcome of pregnancy in women with a previous history of infertility. Br J Obstet Gynecol 1991;98:1087-92.
  9. Pregnancy outcomes after assisted reproductive technology. SOGC guidelines. J Obstet Gynecol can 2006;28(3):220-33.
  10. Treatment related and treatment-independent deliveries among infertile couples, a long-term follow-up. Acta Obstet Gynecol Scand 1997;76:238-43.
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