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JAYPEE JOURNALS
International Scientific Journals from Jaypee
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List of All Articles
1.  Research Article
A Case-Control study of Body Mass Index and Infertility in Algerian Women (Sidi Bel Abbes, West of Algeria)
Hichem Abdessalem MAÏ, Abbassia Demmouche
[Year:2015] [Month:September-December] [Volume:6 ] [Number:3] [Pages:43] [Pages No:103-107] [No of Hits : 1594]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1110 | FREE

ABSTRACT

Introduction: The prevalence of obesity and female infertility in Algeria has increased in past decades, and recent study are showing a relationship between body mass index (BMI) and the risk of female infertility, suggesting that obesity is a risk factor for infertility. In order to evaluate the risk of infertility associated with BMI, we conducted a case-control study.

Materials and methods: The relationship between BMI and female infertility was investigated in a case-control study of 256 infertile cases and 326 fertile control subjects. The BMI of infertile women was compared with the BMI of the control fertile group. Odds ratios (ORs) was calculated as measures of relative risk of infertility associated with BMI.

Results: Multiple analyses showed significant association between various measures of BMI and female infertility in this population. An association between BMI and infertility was observed for the overweight (25.00-29.99 kg/m2; odds ratio = 2.23; p = 0.021; 95% confidence interval, 1.52-3.25) and obese group (> 30 kg/m2; odds ratio = 3.26; p = 0.019; 95% confidence interval, 1.62-6.58) compared to the normal weight group. However, no association was found between underweight and infertility (BMI < 20 Kg/m2, odds ratio = 0.96; p = 0.063; 95% confidence interval, 0.57-1.63).

Conclusion: The present study confirms the results that the previously reported research have shown and affirm that an negative association exist between obesity and overweight with fertility, this association might be influenced by other factors, that’s why larger and more research in the Algerian population are needed.

Keywords: Algeria, Body mass index, Female infertility, Obesity, Overweight.

How to cite this article: MAÏ HA, Demmouche A. A Case- Control study of Body Mass Index and Infertility in Algerian Women (Sidi Bel Abbes, West of Algeria). Int J Infertil Fetal Med 2015;6(3):103-107.

Source of support: Nil

Conflict of interest: None

 
2.  Review Article
Granulocyte Colony Stimulating Factor for Treatment of Thin Endometrium in Assisted Reproduction Technology Cycles
Mohan S Kamath, Prasad Lele
[Year:2015] [Month:September-December] [Volume:6 ] [Number:3] [Pages:43] [Pages No:97-102] [No of Hits : 702]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1109 | FREE

ABSTRACT

Granulocyte colony stimulating factor (G-CSF), a glycoprotein, belongs to colony stimulating factor family and mainly regulates the growth and differentiation of granulocytes. However, it also plays an important role in endometrial stromal cell decidualization, ovulation, implantation, placental metabolism, trophoblast development and endometrial regeneration. It is due to these effects, it has been used in difficult clinical scenarios, such as unresponsive thin endometrium during assisted reproductive technology treatment, repeated implantation failure and recurrent miscarriages. Most of the studies have investigated its use in thin endometrium. In this review, we have summarized the current updated evidence with regards to use of G-CSF in women with thin endometrium.

Keywords: Assisted reproductive technology, Granulocyte colony stimulating factor, Thin endometrium.

How to cite this article: Kamath MS, Lele P. Granulocyte Colony Stimulating Factor for Treatment of Thin Endometrium in Assisted Reproduction Technology Cycles. Int J Infertil Fetal Med 2015;6(3):97-102.

Source of support: Nil

Conflict of interest: None

 
3.  Editorial
Editorial
Kamini A Rao
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:vii] [No of Hits : 684]
Full Text PDF | Abstract | FREE

ABSTRACT

Dear Readers,
Greetings and good wishes!!
Gonadotropin-releasing hormone (GnRH) antagonists can be used to prevent luteinizing hormone surge during controlled ovarian stimulation without hypoestrogenic side effects, flare up, or long downregulation period associated with agonists. It acts through competitive binding to pituitary GnRH receptors, which allows their use at any time during the follicular phase. It is well-proven that it is associated with lower incidence of ovarian hyperstimulation syndrome and it has got comparable clinical outcomes with agonist protocols. To throw more light on this matter, we have a review article by Dr. Divya Sardana on antagonists.

 
4.  Research Article
Novel Design of an Intrauterine Insemination Cannula
Ritvik Vasan
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:15-19] [No of Hits : 651]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1095 | FREE

ABSTRACT

Intrauterine insemination (IUI) is a method of assisted conception that involves transfer of fast moving sperms using an IUI cannula into the uterine cavity at the time of anticipated (or expected) ovulation, thereby increasing chance of pregnancy.
Existing cannulas are designed to be easy to use, harmless to the cervix/endometrium, capable of negotiating the cervical cavity, and to avoid the reflux of inseminate fluid. Some of the factors which influence success of pregnancy are actual number of motile sperms, number of sperms with normal morphology, volume of inseminate and sterility during procedure. This paper proposes a novel ‘completely closed loop’ design for an IUI cannula that ensures complete emptying of washed sperm during insemination, leaving no dead space while ensuring sterility during procedure.

Keywords: Intrauterine insemination, Cannula, Insemination, Catheter, Stillet.

How to cite this article: Vasan R. Novel Design of an Intrauterine Insemination Cannula. Int J Infertil Fetal Med 2015;6(1): 15-19.

Source of Support: This work was supported by Manipal Ankur, Bengaluru, India.

Conflict of Interest: None

Date of Received: 08-01-15

Date of Acceptance: 10-02-15

Date of Publication: April 2015

 
5.  Original Article
Identification of Fetal Growth Patterns with Customized Growth Charts: A prospective study in South India
Badanahatti Radhika, Vavilala Suseela, Praveen Kumar Nirmalan
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:30-34] [No of Hits : 552]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1098 | FREE

ABSTRACT

Aim: To determine the diagnostic effectiveness of symphysis fundus height (SFH) measures plotted on customized growth charts for the identification of fetal growth patterns in a tertiary care perinatal center in south India.

Materials and methods: Serial SFH of pregnant women with singleton babies booked for antenatal care up to 22 weeks was measured from 24 weeks of gestation and plotted on customized growth charts that were developed using the gestation related optimal weight (GROW) software downloaded from www.gestation.net to identify fetal growth patterns. Fetal growth patterns were also ascertainedusing ultrasound in the antenatal period and confirmed at birth using a neonatal growth classification. The diagnostic effectiveness of SFH was compared with ultrasound and neonatal classifications using sensitivity, specificity, area under the ROC curve and likelihood ratio tests.

Results: The study included 666 pregnant women who presented at the antenatal clinics from January 2010 to October 2010. On ultrasound examination, 564 (84.6%) fetuses were AGA, 78 (11.7%) fetuses were LGA and 19 (2.9%) were SGA and 5 (0.8%) showed crossing centile from higher to lower pattern. On serial SFH measures, 426 (64.0%) of the fetuses were normal growth, 180 (27.0%) were excessive growth and 40 (6.0%) were slow growth. Serial SFH measures had a positive likelihood ratio of 4.7 (8.5 for USG) for the identification of SGA and a negative likelihood ratio of 0.06 for the detection of LGA.

Conclusion: The SFH measures plotted on a customized GROW curve have the potential to develop into a low cost screening tool to identify fetuses with altered growth. The diagnostic effectiveness of SFH plotted on customized growth charts has to be improved further through the development of appropriate customized growth charts for India before application on a larger scale.

Keywords: Fetal growth, Growth curves, SGA, LGA, Customization, Grow.

How to cite this article: Radhika B, Suseela V, Nirmalan PK. Identification of Fetal Growth Patterns with Customized Growth Charts: A prospective study in South India. Int J Infertil Fetal Med 2015;6(1):30-34.

Source of Support: The study was supported by the Fernandez Hospital Educational and Research Foundation, Hyderabad.

Conflict of Interest: None

Date of Received: 22-01-15

Date of Acceptance: 15-03-15

Date of Publication: April 2015

 
6.  Research Article
Combined Tamoxifen and L-Carnitine Therapies for the Treatment of Idiopathic Male Infertility Attending Intracytoplasmic Sperm Injection: A Randomized Controlled Trial
Milat Haje, Kameel Naoom
[Year:2015] [Month:January-April] [Volume:6 ] [Number:1] [Pages:42] [Pages No:20-24] [No of Hits : 506]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1096 | FREE

ABSTRACT

Aim: The aim of the present study is to evaluate the fertility outcomes of intracytoplasmic sperm injection (ICSI) as well as sperm count, motility and morphology in couples with infertile male partners exhibiting idiopathic oligoasthenozoospermia (OA) and treated with tamoxifen citrate and/or L-carnitine.

Materials and methods: In this randomized controlled trail, couples with female cause of infertility were excluded. Only couples with male cause of infertility with idiopathic OA were admitted to this study and randomly assigned into four different groups of treatments as follow: Group A (n = 45) received an anti-estrogen compound (tamoxifen 20 mg/day), group B (n = 20) received L-carnitine (1000 mg/day), group C (n = 34) received tamoxifen 20 mg/day plus L-carnitine 1000 mg/day, whereas group D (n = 29) received placebo. Treatments were continued for 3 to 6 months.

Results: Treatment groups of A, B, and C showed an overall improvement in the tested parameters of sperm when compared to the control group that showed an overall reduction in those parameters after termination of the treatment. In this context, sperm count increased from 7.58 ± 2.93 × 106/ml before treatment to 10.81 ± 1.84 × 106/ml after treatment in group A (p = 0.016). Similarly, sperm count increased from 5.32 ± 2.09 × 106/ml to 8.92 ± 2.29 × 106/ml in group C (p = 0.01). Patients from group C did not only have an improved total motility of sperm from 8.03 ± 1.59% to 13.78 ± 3.85% (p = 0.045) but also an improved sperm normal morphology from 0.88 ± 0.45% to 1.99 ± 0.71% (p = 0.026). Patients from group A or C exhibited an improved ICSI outcomes when compared to those in patients from group B or D (48.9 or 48.3 vs 16.6 or 20, respectively, p = 0.46).

Conclusion: It is concluded that administration of tamoxifen and L-carnitine can improve both sperm parameters of fertility and ICSI outcomes. Combined tamoxifen and L-carnitine treatments result in maximum therapeutic effect in men with idiopathic OA.

Keywords: Tamoxifen, L-Carnitine, Male infertility, ICSI .

How to cite this article: Haje M, Naoom K. Combined Tamoxifen and L-Carnitine Therapies for the Treatment of Idiopathic Male Infertility Attending Intracytoplasmic Sperm Injection: A Randomized Controlled Trial. Int J Infertil Fetal Med 2015;6(1):20-24.

Source of Support: Nil.

Conflict of Interest: None

Date of Received: 10-01-15

Date of Acceptance: 25-03-15

Date of Publication: April 2015

 
7.  Review Article
Fibroids and Infertility
Harpreet Kaur, Kamini A Rao
[Year:2014] [Month:January-April] [Volume:5 ] [Number:1] [Pages:31] [Pages No:1-7] [No of Hits : 1404]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1071 | FREE

ABSTRACT

Fibroids are the commonest benign tumors of female genital tract. Though fibroids may not be a sole cause for infertility in majority of cases, but it has been seen that there is an improvement in pregnancy rates after myomectomy. Fibroids that distort the uterine cavity and large intramural fibroids are shown to be associated with adverse effects on reproductive function. Available evidence suggests that submucosal, intramural, and subserosal ?broids interfere with fertility in decreasing order of importance. In infertile women and those with recurrent pregnancy loss, myomectomy should be considered only after a thorough evaluation has been completed. Medical management of fibroids has no role in treatment of fertility rather it might lead to delay in the final treatment for infertility. Preoperative medical treatment with a GnRH agonist should be considered for women who are anemic and those undergoing hysteroscopic myomectomy. Subserosal fibroids have least effect on fertility, so they do not need removal before infertility treatment.

Keywords: Fibroids, infertility, myomectomy, In vitro fertilization.

Keymessage: Fibroids are important cause of infertility; Removal of submucousal fibroids is warranted before IVF.

Search methodology: Data were sourced from the electronic database PubMed, MEDLINE, OVID, Cochrane Database of systematic reviews and published guidelines on fibroids and infertility. Abstracts from papers and posters presented at the international meetings, published and unpublished studies, and expert opinion was considered.

How to cite this article: Kaur H, Rao KA. Fibroids and infertility. Int J Infertil Fetal Med 2014;5(1):1-7.

Source of support: Nil

Conflict of interest: None

Date of Received: 30-03-14

Date of Acceptance: 20-04-14

Date of Publication: April 2014

 
8.  Editorial
Editorial
Kamini A Rao
[Year:2014] [Month:January-April] [Volume:5 ] [Number:1] [Pages:31] [Pages No:iv] [No of Hits : 1367]
Full Text PDF | Abstract | FREE

ABSTRACT

A few months ago, TOG, "The Obstetrician & Gynecologist", the official journal of the Royal College of Obstetrician and Gynaecology (RCOG) published an article by Jolly Joy and Neil McClure entitled "The art of reviewing a paper". As an editor, I cannot overemphasize the importance of such an article. Despite the routine publication of peer-reviewed articles in all quality journals, there is no formal training for peer reviewers. The article by Joy and McClure takes you through the basic principles and responsibilities of the review process while emphasizing the importance of ensuring quality control in a fair and appropriate way that justifies the reviewer’s responsibility to the author as well as to the editor of the journal. The point that I would like to put across here is that every editor needs a strong team of reviewers who respond promptly and ensure that the submission is reviewed and returned within the stipulated time frame. An invitation to review an article is a recognition of your standing in your area of expertise and undoubtedly an honor. However, while recognizing the invitation as an honor, many practicing clinicians also consider it an unnecessary burden on their time, leading to inordinately delayed responses. Delays in the review process due to indifference of peer reviewers remain the bane of every editor. I would like to appeal to all reviewers to devote your time and expertise selflessly in the interest of raising the quality of our publications.

 
9.  Original Article
Fetomaternal Outcome in Preterm Premature Rupture of Membrane
Minakeshi Rana, sharda patra, Manju Puri, Shubha Sagar Trivedi
[Year:2014] [Month:January-April] [Volume:5 ] [Number:1] [Pages:31] [Pages No:18-21] [No of Hits : 1337]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1075 | FREE

ABSTRACT

This prospective observational study was carried out to study the fetomaternal outcome in women with preterm premature rupture of membrane (PPROM) between 24 and 36 weeks of gestation.

Materials and methods: A total of 150 pregnant women between 24 and 36 weeks gestation with PROM were subjected to detailed history and examination. Each patient was followed till her delivery and fetomaternal outcome was recorded gestation-wise between 24 and 28 weeks (n = 15), 28 and 32 weeks (n = 30), 32 and 34 weeks (n = 90), and 34 and 36 weeks (n = 15).

Result: The mean latency period from membrane rupture to delivery decreased from 15 days at 24 to 28 weeks, 11 days at 28 to 32 weeks to 4.4 days at 32 to 34 weeks to 2.1 days at 34 to 36 weeks. Majority of women delivered vaginally. The rate of spontaneous labor increased as the gestational age at admission increased, the difference between rate of spontaneous labor of 67% at 28 to 32 weeks and 86% at 34 to 36 weeks was statistically significant (p = 0.001). The indications for induction of labor were intrauterine fetal death, gross oligohydramnios, and clinical chorioamnionitis. The most common complication was clinical chorioamnionitis (6%) and postpartum sepsis (6%). The perinatal outcome was favorable in majority of cases and improved with the increase in gestational age at PROM. The overall perinatal mortality was 9.3%.

Conclusion: Management of PPROM involves complete evaluation of risks and benefits of conservative management. Wherever possible, the treatment should be directed toward conserving the pregnancy with prophylactic use of antibiotics and steroids thereby reducing fetal-maternal morbidity and mortality. However, termination of pregnancy should be considered at the earliest suspicion of chorioamnionitis.

Keywords: Preterm premature rupture of membranes, chorioamnionitis, maternal outcome, neonatal outcome.

How to cite this article: Rana M, patra s, Puri M, Trivedi SS. Fetomaternal Outcome in Preterm Premature Rupture of Membrane. Int J Infertil Fetal Med 2014;5(1):18-21.

Source of support: Nil

Conflict of interest: None

Date of Received: 10-09-13

 
10.  Case Report
Globozoospermia
Sandhya Krishnan
[Year:2014] [Month:January-April] [Volume:5 ] [Number:1] [Pages:31] [Pages No:27-29] [No of Hits : 1152]
Full Text PDF | Abstract | DOI : 10.5005/jp-journals-10016-1077 | FREE

ABSTRACT

Globozoospermia is a severe form of terato-zoospermia characterized by round-headed acrosome-less spermatozoa. The main problem is low fertilization rate due to lack of acrosome. We report successful pregnancy outcome of intracytoplasmic sperm injection (ICSI) treatment in a case of globozoospermia.

Keywords: Globozoospermia, male infertility, round-headed sperm cells.

How to cite this article: Krishnan S. Globozoospermia. Int J Infertil Fetal Med 2014;5(1):27-29.

Source of support: Nil

Conflict of interest: None

Date of Received: 09-02-14

Date of Acceptance: 18-03-14

Date of Publication: April 2014

 
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